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Type d'Item : Item , « Acknowledge me! » : le récit et le référent théâtral dans la lutte professionnelle contemporaine(Université d'Ottawa | University of Ottawa, 2026-08-13) Adam, Ali; Beddows , JoëlLa lutte professionnelle est une forme spectaculaire populaire qui fait salle comble partout où elle est présentée, que ce soit dans les immenses stades ou dans les salles communautaires plus modestes. Pourtant, malgré cette popularité, les recherches savantes sur le sujet demeurent peu nombreuses. Cette étude tente de remplir ce vide en analysant certains liens possibles entre la lutte professionnelle et le théâtre. Compte tenu des similitudes parfois étonnantes entre les deux formes artistiques, nous postulons qu’il est possible de comprendre la lutte professionnelle en tant que représentation théâtrale. Pour ce faire, la mise en scène et l’utilisation du récit d’un corpus constitué de trois matchs seront analysées. Plus spécifiquement, la description des fables scéniques et des articulations du jeu du comédien, des costumes, des accessoires, du son et de la musique permettront de cerner la pertinence, ainsi que certaines limites, de cette hypothèse. Enfin, cette étude se veut sciemment comparatiste et internationaliste puisque chaque match du corpus est issu de trois traditions différentes rattachées quant à elles à trois pratiques nationales très éloignées les unes des autres : le premier chapitre porte sur un match de la World Wrestling Entertainment, en Amérique du Nord; le deuxième traite de la WWE NXT UK en Angleterre; et le dernier aborde un match de la Stardom au Japon. Professional wrestling is a popular form of entertainment that draws full houses wherever it is staged, whether in huge stadiums or in more modest community halls. Yet, despite this popularity, scholarly research on the subject remains scarce. This study aims to fill this gap by analysing some of the possible links between professional wrestling and theatre. Given the often-striking similarities between the two practices, professional wrestling can be understood as a theatrical performance. To this end, the staging and narrative structure of a corpus comprising three matches will be analysed. More specifically, an examination of the narrative arcs and the interplay between the wrestlers’ performance, costumes, props, sound and music will help to identify the validity, as well as certain limitations, of this hypothesis. Finally, this study is deliberately comparative and international in scope, as each match draws on three different traditions, which in turn are linked to three national practices that are very distinct from one another: the first chapter focuses on a World Wrestling Entertainment match in North America; the second deals with WWE NXT UK in England; and the final chapter examines a Stardom match in Japan.Type d'Item : Item , Vacuum Integrity and Leak Localization in Polymer Composite Manufacturing(Université d'Ottawa | University of Ottawa, 2026-08-12) Roberts, David; Robitaille, FrancoisVacuum infusion is widely used to manufacture large composite structures where the vacuum integrity of the vacuum bag assembly governs the quality of the resulting laminate. Before resin is infused, manufacturers verify integrity with a vacuum-drop test which confirms whether a leak is present but gives no information about where it is located. When the vacuum-drop test fails, the leak is found by a manual search that is slow, depends on skilled operators and scales poorly to large parts. Published localization methods address this only partially: they infer leak position from flow measured at the vacuum boundary while the pump is operating, rather than from pressure measurements across the part. This thesis investigates whether a distributed array of pressure transducers installed beneath the vacuum film can localize a leak during the vacuum-drop test. Twenty pressure transducers recorded gauge pressure at 1Hz across a 1.86m × 1.20m fabric stack through fourteen experiments, spanning ten pinhole positions and two needle diameters with each leak introduced during pump-off vacuum-drop conditions. In all fourteen experiments the PT(s) recording the largest dP/dt gradient was the one nearest the pinhole. The leak region is identified from the spatial pattern of dP/dt across the array. This pattern proved robust to baseline vacuum drift and per-sensor calibration offsets. Although the peak magnitude varied between nominally identical punctures, the identified location did not. The work demonstrates, at laboratory scale, a route to localizing vacuum film leaks during a vacuum-drop test already performed in industry, using low-cost PTs and standard data acquisition hardware.Type d'Item : Item , Regulation of Irf2bp2 and Deficiency in Sepsis-Induced QT Prolongation(Université d'Ottawa | University of Ottawa, 2026-08-12) Duong, An; Stewart, Alexandre F. R.The innate immune system is the body’s first line of defence against viral and bacterial pathogens, and the inflammatory response is crucial in maintaining a healthy cellular environment. Interferon regulatory factor 2 binding protein 2 (IRF2BP2), a zinc finger transcriptional corepressor highly expressed in macrophages, suppresses the interferon response and inflammation. In humans, individuals who carry two copies of a genetic variant (rs3045215) that deletes 9 nucleotides from the long 3’UTR of IRF2BP2 have lower IRF2BP2 protein expression in white blood cells and increased risk of coronary atherosclerosis and calcification. The first objective of this thesis was to determine how expression of IRF2BP2 is regulated by its 3’UTR and how this deletion variant leads to lower protein expression. For this, a combination of cellular and molecular techniques were used. First, we showed that the deletion variant is unable to interact with eukaryotic initiation factor 4H (eIF4H), a translation initiation factor that is required for the unwinding of GC-rich mRNA secondary structures. The 9-nucleotide deletion disrupts a proposed stem-loop structure, which is critical for interaction with eIF4H. siRNA knockdown of eIF4H preferentially disrupts translation of the non-deletion variant of the IRF2BP2 3’UTR, but not the deletion allele, revealing an essential role for the 9-nucleotide sequence in interacting with eIF4H. Previous work from our lab demonstrated that expression of IRF2BP2 is downregulated in response to LPS in bone marrow-derived macrophages (BMDM), attenuating the anti-inflammatory function of IRF2BP2 in the presence of endotoxins. We further uncovered a role for IRF2BP2 protein in binding to its own 3’UTR in the cytoplasm in response to LPS, suggesting an autoregulatory function. This response is lost in the rs3045215 deletion variant, demonstrating the importance of the 9-nnucleotide sequence in the 3’UTR in regulating its own expression. We also confirm that a single nucleotide polymorphism (rs7545855) located in exon 1 of IRF2BP2 that is co-inherited with rs3045215 does not confer any functional differences with respect to the autoregulatory mechanism. Because IRF2BP2 deficiency leads to proinflammatory macrophages, we asked whether mice lacking IRF2BP2 in their bone marrow-derived macrophages would display a heightened response to lipopolysaccharides with respect to their cardiac electrophysiology, which is sensitive to inflammatory signaling. By using LysMCre/Irf2bp2flx/flx mice whose macrophages are prone to inflammation, we revealed that female mice lacking IRF2PB2 in their BMDMs are uniquely protected against severe LPS-induced QT prolongation, an indicator of delayed ventricular repolarization. These female mice displayed an upregulation of growth differentiation factor 3 (GDF3) mRNA and protein, a member of the TGFβ family of signaling molecules that protects mice against LPS-mediated cardiac dysfunction. Our ECG studies revealed that pre-treating male wild type mice with recombinant GDF3 (rmGDF3) 12 hours prior to exposure to LPS similarly protected them from severe LPS-induced QT prolongation. Mechanistically, we discovered that short term exposure to LPS results in the upregulation of the sodium-calcium exchanger (NCX) in the mouse myocardium, which is reduced in mice pre-treated with rmGDF3. Our in vitro studies revealed that rmGDF3 blocks the uptake of toll-like receptor 4 (TLR4) and TRIF signaling in HL-1 cardiomyocytes and neonatal rat ventricular myocytes, providing insight into the possible mechanisms underlying this protection. Together, the data provide valuable insight into the mechanisms governing expression of IRF2BP2 in response to endotoxins. As well, our findings reveal sex-specific differences in the response to IRF2BP2 deficiency, with males showing an increased risk of coronary artery calcification, while females are protected from LPS-induced QT prolongation through the action of increased GDF3. Our results suggest that GDF3 should be further investigated as a potential therapeutic for protecting patients against QT prolongation in the face of inflammatory diseases, who face an increased risk of ventricular arrhythmias and sudden cardiac death.Type d'Item : Item , Graph-Based Learning for Intelligent Network Management: Adaptive Restoration, Reliability Prediction, and Traffic Forecasting(Université d'Ottawa | University of Ottawa, 2026-08-12) Ampratwum, Isaac; Nayak, AmiyaModern communication networks are becoming increasingly complex due to rising traffic demands, stringent reliability requirements, and the need for adaptive management across optical and wireless infrastructures. Traditional rule-based and static management approaches are often inadequate for handling the structural, temporal, and operational complexity of these environments. This thesis investigates Graph Neural Networks (GNNs) as a unifying learning paradigm for intelligent network management, and demonstrates how task-specific integration with reinforcement learning, temporal sequence models, and evolutionary optimization can improve decision-making across diverse networking problems. Three representative network management challenges are addressed. First, a GNN-enhanced deep reinforcement learning framework is developed for dynamic restoration in Wavelength Division Multiplexing (WDM) networks. By encoding topology and failure states as graph-structured inputs, the framework enables topology-aware routing and wavelength assignment, achieving faster and more effective recovery than conventional heuristic restoration methods. Second, a graph-based predictive framework is proposed for proactive radio link failure prediction in 5G networks. By combining spatial relationships among neighboring sites with temporal and environmental context, the model improves the early detection of service disruptions and supports proactive reliability management. Third, a spatio-temporal GNN-based traffic forecasting model, augmented with Transformer learning and Genetic Algorithm-based hyperparameter optimization, is introduced for 6G network environments. This model captures both structural and temporal traffic dependencies, improving forecasting accuracy and enabling more effective predictive resource allocation. Taken together, these contributions show that graph-based learning provides a coherent and effective foundation for intelligent network management across resilience, reliability, and forecasting tasks. Rather than proposing a single universal architecture for all network problems, this thesis demonstrates how a common graph-centered perspective can be adapted to different management objectives through appropriate learning and optimization mechanisms. The results establish GNN-based modeling as a practical pathway toward more adaptive, predictive, and autonomous communication networks.Type d'Item : Item , Telehealth and Occupational Well-Being Among Family Physicians: A Structural Equation Model of Pleasure, Engagement, and Meaning(Université d'Ottawa | University of Ottawa, 2026-08-12) Kumar, Trisha; Durand, François; Ferris, LanceTelehealth has become a routine feature of Canadian primary care, yet its implications for the physicians who deliver it remain underexamined. Drawing on Well-Being Theory and the Job Demands–Resources model, this thesis examines how telehealth usage relates to family physicians’ pleasure, engagement, and meaning at work through five mechanisms: work autonomy, technological strain, cognitive overload, relational depth, and interpersonal connection. A cross-sectional survey of 190 Canadian family physicians was analyzed using structural equation modelling. The hypothesized model was rejected, but three of the six indirect effects were supported. Higher telehealth use was associated with lower well-being through greater digital encroachment and exhaustion and through reduced relational depth, which operated as a broad resource across all three well-being dimensions. Implications for the organization of virtual primary care are discussed.