Direct arylation of aromatic rings using palladium catalysis

Abstract

The first section illustrates the novel route to access the biphenyl motif. Starting from simple materials, nitroarenes and aryl halides, we are able to obtain different cross-coupled products in good to moderate yields using palladium as a catalyst. The optimization of the reaction conditions as well as the various biaryl motifs obtained are described.* The second section summarizes our efforts towards the development of universal reaction conditions that can be used for the arylation of a wide range of heterocycles. Although direct arylation products are available in the literature, no broadly accessible method is available yet. The heterocycles described are limited to azoles and the various motifs obtained are illustrated.* *Please refer to dissertation for diagrams.