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Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions

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dc.contributor.authorBuchler, Ariel
dc.contributor.authorMunch, Maxime
dc.contributor.authorFarber, Gedaliah
dc.contributor.authorZhao, Xiaoling
dc.contributor.authorAl-Haddad, Rami
dc.contributor.authorFarber, Eadan
dc.contributor.authorRotstein, Benjamin H
dc.date.accessioned2022-08-26T21:09:37Z
dc.date.available2022-08-27T09:00:11Z
dc.date.issued2022
dc.description.abstractOverexpression and activation of matrix metalloproteinase-13 (MMP-13) within atheroma increases susceptibility to plaque rupture, a major cause of severe cardiovascular complications. In comparison to pan-MMP targeting [18F]BR-351, we evaluated the potential for [18F]FMBP, a selective PET radiotracer for MMP-13, to detect extracellular matrix (ECM) remodeling in vascular plaques possessing markers of inflammation.en_US
dc.embargo.terms2022-07-06
dc.identifier.doi10.1007/s11307-021-01626-9en_US
dc.identifier.issn1536-1632en_US
dc.identifier.urihttp://link.springer.com/article/10.1007/s11307-021-01626-9en_US
dc.identifier.urihttp://hdl.handle.net/10393/43964
dc.identifier.urihttps://doi.org/10.20381/ruor-28177
dc.language.isoenen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAtherosclerosisen_US
dc.subjectAutoradiographyen_US
dc.subjectInflammationen_US
dc.subjectMatrix metalloproteinasesen_US
dc.subjectPositron emission tomographyen_US
dc.subjectRadiotraceren_US
dc.subjectRemodelingen_US
dc.subjectVulnerable plaquesen_US
dc.subjectAnimalsen_US
dc.subjectExtracellular Matrixen_US
dc.subjectMatrix Metalloproteinase 13en_US
dc.subjectMiceen_US
dc.subjectTissue Distributionen_US
dc.subjectAtherosclerosisen_US
dc.subjectPlaque, Atheroscleroticen_US
dc.titleSelective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesionsen_US
dc.typeArticleen_US

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Biochimie, microbiologie et immunologie // Biochemistry, Microbiology and Immunology