Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions
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Abstract
Overexpression and activation of matrix metalloproteinase-13 (MMP-13) within atheroma increases susceptibility to plaque rupture, a major cause of severe cardiovascular complications. In comparison to pan-MMP targeting [18F]BR-351, we evaluated the potential for [18F]FMBP, a selective PET radiotracer for MMP-13, to detect extracellular matrix (ECM) remodeling in vascular plaques possessing markers of inflammation.
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Keywords
Atherosclerosis, Autoradiography, Inflammation, Matrix metalloproteinases, Positron emission tomography, Radiotracer, Remodeling, Vulnerable plaques, Animals, Extracellular Matrix, Matrix Metalloproteinase 13, Mice, Tissue Distribution, Atherosclerosis, Plaque, Atherosclerotic