Cabinet VR, Recherche - Publications // Office VP, Research - Publications

Permanent URI for this collectionhttps://hdl.handle.net/10393/12780

Browse

Now showing 1 - 18 of 18

Partager la recherche autrement : mobiliser les connaissances à l’aide des ressources éducatives libres (REL)
(2026-03-04) Brunet, Mélanie; Bear, Savage; Boulanger, Josée; Richards, Jenna
Cette séance bilingue, tenue dans le cadre du Mois de l’éducation ouverte 2026, examine comment les ressources éducatives libres (REL) soutiennent et renforcent la mobilisation des connaissances dans les milieux universitaires et communautaires et mets en lumière l’importance particulière de la cocréation. Panélistes et ressources en vedette : Savage Bear, McMaster Indigenous Research Institute (MIRI), McMaster University Indigenous Canada : https://www.ualberta.ca/en/admissions-programs/online-courses/indigenous-canada/index.html Josée Boulanger, HUMAlab, Collège La Cité La communication pour une meilleure santé : https://ecampusontario.pressbooks.pub/cmnsantedi/ Jenna Richards, Xenia Concerts et Ottawa Chamberfest Améliorer l’inclusivité et l’accessibilité dans les arts de la scène : http://hdl.handle.net/10393/50568 Lien vers l'engistrement sur YouTube : https://www.youtube.com/watch?v=Vu4J13y5TUQ
Sharing Research Differently: Mobilizing Knowledge with Open Educational Resources (OER)
(2026-03-04) Brunet, Mélanie; Bear, Savage; Boulanger, Josée; Richards, Jenna
This bilingual session, held as part of Open Education Week 2026, examines how open educational resources (OER) support and strengthen knowledge mobilization in academic and community settings while highlighting the particular importance of co-creation. Featured speakers and resources: Savage Bear, McMaster Indigenous Research Institute (MIRI), McMaster University Indigenous Canada: https://www.ualberta.ca/en/admissions-programs/online-courses/indigenous-canada/index.html Josée Boulanger, HUMAlab, Collège La Cité La communication pour une meilleure santé: https://ecampusontario.pressbooks.pub/cmnsantedi/ Jenna Richards, Xenia Concerts and Ottawa Chamberfest Improving Inclusivity and Accessibility in the Performing Arts: http://hdl.handle.net/10393/50567 Link to the recording on YouTube: https://www.youtube.com/watch?v=Vu4J13y5TUQ
Rapport annuel de l'Unité Connexions Recherche 2020
(2021) Girard, Marie-Eve
L’unité Connexions Recherche de l’Université d’Ottawa fait partie du Service de gestion de la recherche (SGR) du Cabinet du vice-recteur à la recherche (CVRR). Elle a été créée aux fins de l’élaboration et de l’implantation de la Stratégie institutionnelle de mobilisation des connaissances 2019-2021 de l’Université. En 2020, la conseillère en mobilisation des connaissances, en collaboration avec de nombreux groupes de l’Université d’Ottawa et avec les membres du comité consultatif de Connexions Recherche, a mis en oeuvre un éventail d’activités en vue de l’atteinte des objectifs de la Stratégie. Ces derniers consistent à : 1) acquérir des connaissances et des compétences de base en matière de mobilisation des connaissances (MdC); 2) promouvoir une culture qui appuie la MdC; 3) faire participer les utilisatrices et utilisateurs des connaissances; et 4) évaluer les résultats et générer des retombées. Le présent rapport donne un aperçu de ce qui a été réalisé.
2020 Research Connections Unit Annual Report
(2021) Girard, Marie-Eve
The uOttawa Research Connections unit is part of Research Management Services in the Office of the Vice-President, Research (OVPR). It was established to develop and implement the University of Ottawa Knowledge Mobilization Institutional Strategy 2019-2021. In 2020, the Research Connections Knowledge Mobilization Advisor, in collaboration with many uOttawa stakeholders and the members of the Research Connections Advisory Committee, implemented a range of activities designed to achieve the strategy objectives. The objectives aim to 1) build foundational knowledge and skills in knowledge mobilization, 2) promote the culture of knowledge mobilization, 3) engage knowledge users and 4) evaluate outcomes and generate impact. This report provides an overview of these accomplishments.
CIHR Knowledge Translation Checklist
(2021) Girard, Marie-Eve
This checklist was developed to help CIHR proposal writers think about all thesections in which knowledge translation can be addressed in a CIHR proposal. Use this checklist to check if you have included in your proposal all the important elements related to knowledge translation that are relevant to your research project in each section of the proposal (proposal summary, methodological approach, timeline,roles and responsibilities or description of partners, knowledge translation plan,budget and participant CV).
IRSC liste de contrôle pour l'application des connaissances
(2021) Girard, Marie-Eve
Cette liste de contrôle a été élaborée pour aider les rédacteurs de propositions pour lesIRSC à réfléchir à toutes les sections dans lesquelles l’application des connaissancespeut être abordée dans une proposition des IRSC. Utilisez cette liste de contrôle pour vérifier si vous avez inclus dans votre propositiontous les éléments importants liés à l’application des connaissances qui sont pertinentspour votre projet de recherche dans chaque section de la proposition (résumé de laproposition, approche méthodologique, calendrier, rôles et responsabilités oudescription des partenaires, application des connaissances, budget et CV desparticipants).
CRSH Liste de contrôle pour la mobilisation des connaissances
(2021) Girard, Marie-Eve
Cette liste de contrôle a été élaborée pour aider les rédacteurs de propositions pour le CRSH àréfléchir à toutes les sections dans lesquelles la mobilisation des connaissances peut êtreabordée dans une proposition du CRSH. Utilisez cette liste de contrôle pour vérifier si vous avez inclus dans votre proposition tous leséléments importants liés à la mobilisation des connaissances qui sont pertinents pour votre projet de recherche dans chaque section de la proposition (résumé de la proposition, approche méthodologique, calendrier, rôles et responsabilités ou description des partenaires, formation desétudiants et
SSHRC Knowledge Mobilization Checklist
(2021) Girard, Marie-Eve
This checklist was developed to help SSHRC proposal writers think about all the sections in which knowledge mobilization can be addressed in a SSHRC proposal.Use this checklist to check if you have included in your proposal all the important elements related to knowledge mobilization that are relevant to your research project in each section of the proposal (proposal summary, methodological approach, timeline, roles and responsibilities or description of partners, student training or training and mentoring, knowledge mobilization plan, budget and participant CV).
Une recherche riche en retombées : Stratégie institutionnelle de mobilisation des connaissances 2019-2021
(2020) Cabinet du Vice-recteur à la recherche
La stratégie de mobilisation des connaissances de l’Université d’Ottawa, que le groupe de travail a définie, s’appuie sur une solide base d’expérience collective et apporte à l’ensemble du milieu de la recherche le soutien dont il a besoin pour mobiliser les connaissances et bonifier l’incidence de ses travaux de recherche. Cette stratégie vise à 1) acquérir des compétences ; 2) promouvoir la culture ; 3) faire participer les utilisateurs des connaissances et 4) évaluer les résultats, produire des retombées.
Research with Impact: Knowledge Mobilization Institutional Strategy 2019-2021
(2020) Office of Vice-President Research
This uOttawa knowledge mobilization strategy, identified by the working group, builds on our collective rich base of expertise and provides the support our entire research community needs to mobilize and increase the impact of their research. The strategy aims to 1) build skills; 2) promote culture; 3) engage knowledge users and 4) evaluate outcomes and generate impact.
Trousse d'enquête pour l'évaluation des besoins en mobilisation des connaissances
(2020) Girard, Marie-Eve
Cette trousse servira de guide pour aider les organismes et les établissements universitaires à effectuer une enquête d’évaluation des besoins en MdC et à s’appuyer sur les résultats de celle-ci pour éclairer leurs décisions et améliorer leurs services de soutien dans ce domaine. Elle contient des lignes directrices, un questionnaire et des modèles à adapter et à utiliser.
Knowledge Mobilization Needs Assessment Survey Toolkit
(2020) Girard, Marie-Eve
This toolkit will allow other organizations and academic institutions to undertake a knowledge mobilization needs assessment survey and to use the results of the survey to inform decisions and improvements in the organization’s knowledge mobilization support services. It contains guidelines, the survey questions and templates to adapt and use.
An Endocardial Pathway Involving Tbx5, Gata4, and Nos3 Required for Atrial Septum Formation
(2010) Nadeaua, Mathieu
In humans, septal defects are among the most prevalent congenital heart diseases, but their cellular and molecular origins are not fully understood. We report that transcription factor Tbx5 is present in a subpopulation of endocardial cells and that its deletion therein results in fully penetrant, dose-dependent atrial septal defects in mice. Increased apoptosis of endocardial cells lacking Tbx5, as well as neighboring TBX5-positive myocardial cells of the atrial septum through activation of endocardial NOS (Nos3), is the underlying mechanism of disease. Compound Tbx5 and Nos3 haploinsufficiency in mice worsens the cardiac phenotype. The data identify a pathway for endocardial cell survival and unravel a cell-autonomous role for Tbx5 therein. The finding that Nos3, a gene regulated by many congenital heart disease risk factors including stress and diabetes, interacts genetically with Tbx5 provides a molecular framework to understand gene–environment interaction in the setting of human birth defects.
The Kruppel-like transcription factor KLF13 is a novel regulator of heart development
(2006) Nemer, Georges; Horb, Marko E.; Nemer, Mona; Nadeau, Mathieu; Lefebvre, Chantal; Lavallée, Geneviève; Andelfinger, Gregor
In human, congenital heart defects occur in 1-2% of live birth but the molecular mechanisms and causative genes remain unidentified in the majority of cases. We have uncovered a novel transcription pathway important for heart morphogenesis. We report that KLF13, a member of the Krüppel-like family of zinc finger proteins, is expressed predominantly in the heart, binds evolutionarily conserved regulatory elements on cardiac promoters and activates cardiac transcription. KLF13 is conserved across species and knockdown of KLF13 in Xenopus embryos lead to atrial septal defects and hypotrabeculation similar to those observed in human or mice with hypomorphic GATA-4 alleles. Physical and functional interaction with GATA-4, a dosage sensitive cardiac regulator, provides a mechanistic explanation for KLF13 action in the heart. The data demonstrate that KLF13 is an important component of the transcription network required for heart development and suggest that KLF13 is a GATA-4 modifier; by analogy to other GATA-4 collaborators, mutations in KLF13 may be causative for congenital human heart disease.
Convergence of Protein Kinase C and JAK-STAT signaling on transcription factor GATA-4
(2005) Lefebvre, Chantal; Wang, Hao; Nemer, Mona; Aries, Anne; Komati, Hiba; Wang, Jun; Paradis, Pierre
Angiotensin II (AII), a potent vasoactive hormone, acts on numerous organs via G-protein-coupled receptors and elicits cell-specific responses. At the level of the heart, AII stimulation alters gene transcription and leads to cardiomyocyte hypertrophy. Numerous intracellular signaling pathways are activated in this process; however, which of these directly link receptor activation to transcriptional regulation remains undefined. We used the ANF gene (NPPA) as marker to elucidate the signaling cascades involved in AII transcriptional responses. We show that ANF transcription is activated directly by the AII type 1 receptor and precedes the development of myocyte hypertrophy. This response maps to a STAT and GATA binding sites and the two elements transcriptionally cooperate to mediate signaling through JAK-STAT and PKC-GATA-4 pathways. PKC phosphorylation enhances GATA-4 DNA binding activity and STAT-1 functionally and physically interacts with GATA-4 to synergistically activate AII and other growth factor-inducible promoters. Moreover, GATA factors are able to recruit STAT proteins to target promoters via GATA binding sites which are sufficient to support synergy. Thus, STAT proteins can act as growth factor inducible coactivators of tissuespecific transcription factors. Interactions between STAT and GATA proteins may provide a general paradigm to understand cell specificity of cytokines and growth factors signaling.
The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of α1-adrenergic signaling
(2005) Nemer, Mona; Paradis, Pierre; Delorme, Bruno; Marttila, Minna; Rahbani, Loulwa; Debrus, Sophie
α1-Adrenergic receptors mediate several biological effects of catecholamines, including the regulation of myocyte growth and contractility and transcriptional regulation of the atrial natriuretic factor (ANF) gene whose promoter contains an α1-adrenergic response element. The nuclear pathways and effectors that link receptor activation to genetic changes remain poorly understood. Here, we describe the isolation by the yeast one-hybrid system of a cardiac cDNA encoding a novel nuclear zinc finger protein, Zfp260, belonging to the Krüppel family of transcriptional regulators. Zfp260 is highly expressed in the embryonic heart but is downregulated during postnatal development. Functional studies indicate that Zfp260 is a transcriptional activator of ANF and a cofactor for GATA-4, a key cardiac regulator. Knockdown of Zfp260 in cardiac cells decreases endogenous ANF gene expression and abrogates its response to α1-adrenergic stimulation. Interestingly, Zfp260 transcripts are induced by α1-adrenergic agonists and are elevated in genetic models of hypertension and cardiac hypertrophy. The data identify Zfp260 as a novel transcriptional regulator in normal and pathological heart development and a nuclear effector of α1-adrenergic signaling.
GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors
(2008) Anttonen, Mikko; Heikinheimo, Markku; Huhtaniemi, Ilpo; Leminen, Arto; Butzow, Ralf; Unkila-Kallio, Leila; Tamminen, Maija; Rahman, Nafis; Nemer, Mona; Rämö, Maarit; Kyrönlahti, Antti
Excessive cell proliferation and decreased apoptosis have been implicated in the pathogenesis of ovarian granulosa cell tumors (GCTs). We hypothesized that transcription factor GATA-4 controls expression of the antiapoptotic factor Bcl-2 and the cell cycle regulator cyclin D2 in normal and neoplastic granulosa cells. To test this hypothesis, a tissue microarray based on 80 GCTs was subjected to immunohistochemistry for GATA-4, Bcl-2, and cyclin D2, and the data were correlated to clinical and histopathological parameters. In addition, quantitative RT-PCR for GATA-4, Bcl-2, and cyclin D2 was performed on 21 human GCTs. A mouse GCT model was used to complement these studies. The role of GATA-4 in the regulation of Bcl2 and ccdn2 (coding for cyclin D2) was studied by transactivation assays, and by disrupting GATA-4 function with dominant negative approaches in mouse and human GCT cell lines. We found that GATA-4 expression correlated with Bcl-2 and cyclin D2 expression in human and murine GCTs. Moreover, GATA-4 enhanced Bcl-2 and cyclin D2 promoter activity in murine GCT cells. Whereas GATA-4 overexpression up-regulated and dominant negative GATA-4 suppressed Bcl-2 expression in human GCT cells, the effects on cyclin D2 were negligible. Our results reveal a previously unknown relationship between GATA-4 and Bcl-2 in mammalian granulosa cells and GCTs, and suggest that GATA-4 influences granulosa cell fate by transactivating Bcl-2.
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
(2005) Bruneau, Benoit G.; Nagy, Andras; Mo, Rong; Nemer, Mona; Black, Brian L.; Hui, Chi-chung; Henkelman, Mark; Davidson, Lorinda; Georges, Romain; Gertsenstein, Marina; Heidt, Analeah B.; Mori, Alessandro D.; Mileikovskaia, Maria; Koshiba-Takeuchi, Kazuko; Arruda, Eric P.; Takeuchi, Jun K
To elucidate the function of the T-box transcription factor Tbx20 in mammalian development, we generated a graded loss-of-function series by transgenic RNA interference in entirely embryonic stem cell-derived mouse embryos. Complete Tbx20 knockdown resulted in defects in heart formation, including hypoplasia of the outflow tract and right ventricle, which derive from the anterior heart field (AHF), and decreased expression of Nkx2-5 and Mef2c, transcription factors required for AHF formation. A mild knockdown led to persistent truncus arteriosus (unseptated outflow tract) and hypoplastic right ventricle, entities similar to human congenital heart defects, and demonstrated a critical requirement for Tbx20 in valve formation. Finally, an intermediate knockdown revealed a role for Tbx20 in motoneuron development, specifically in the regulation of the transcription factors Isl2 and Hb9, which are important for terminal differentiation of motoneurons. Tbx20 could activate promoters/enhancers of several genes in cultured cells, including the Mef2c AHF enhancer and the Nkx2-5 cardiac enhancer. The Mef2c AHF enhancer relies on Isl1- and Gata-binding sites. We identified a similar Isl1 binding site in the Nkx2-5 AHF enhancer, which in transgenic mouse embryos was essential for activity in a large part of the heart, including the outflow tract. Tbx20 synergized with Isl1 and Gata4 to activate both the Mef2c and Nkx2-5 enhancers, thus providing a unifying mechanism for gene activation by Tbx20 in the AHF. We conclude that Tbx20 is positioned at a critical node in transcription factor networks required for heart and motoneuron development where it dose-dependently regulates gene expression.

Browse

Recent Submissions