Pharmacological and metabolic parameters of [18F]flubrobenguane in clinical imaging populations
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Creative Commons
Abstract
Cardiac sympathetic nervous system molecular imaging has demonstrated prognostic value. Compared with meta-[11C]hydroxyephedrine, [18F]flubrobenguane (FBBG) facilitates reliable estimation of SNS innervation using similar analytical methods and possesses a more convenient physical half-life. The aim of this study was to evaluate pharmacokinetic and metabolic properties of FBBG in target clinical cohorts.
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Keywords
Flubrobenguane, PET, fluorine-18, metabolism, sympathetic nervous system, Humans, Positron-Emission Tomography, Heart, Guanidines, Cardiomyopathies
Citation
J. Nucl. Cardiol. 2023, 30(5), 2089–2095