L'hypothyroïdisme sous-clinique chez la femme préménopausée: Influences sur la composition corporelle, le profil lipidique et la balance énergétique

Abstract

The aim of this study was to determine if subclinical hypothyroidism revealed by elevated thyroid stimulating hormone (TSH) levels affects body composition, lipids profil and energy balance in healthy premenopausal women. A cross sectional design of the first year from the MONET (Montreal Ottawa New Emerging Team) cohort was done. The sample consisted of 94 premenopausal women. We measured body composition by dual-energy X-ray absorptiometry, visceral and subcutaneous adipose tissue area by CT-scan, physical activity energy expenditure by omnidirectional accelerometer (Actical), resting energy expenditure by indirect calorimetry, and food intake by food diary. Plasma lipid profile (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, apolipoprotein B), TSH, free thyroxin (FT4) levels were also measured. The results indicate that elevated TSH levels within normal range in healthy premenopausal women do not seem to affect body composition, lipid profile and energy balance parameters in healthy premenopausal women.