Insulin-like growth factor-II (IGF2) gene of zebrafish and its use as a biogenetic marker for the assay of epigenetic toxin exposure

dc.contributor.author	Alazzabi, Mufida
dc.date.accessioned	2013-11-07T17:24:59Z
dc.date.available	2013-11-07T17:24:59Z
dc.date.created	2004
dc.date.issued	2004
dc.degree.level	Masters
dc.degree.name	M.Sc.
dc.description.abstract	The purpose of this research was to determine whether expression analysis of the IGF2 gene in zebrafish, a gene whose transcription is known to be regulated by DNA methylation in mammals, can be used as a marker or indicator of DNA methylation due to toxin exposure in fish embryos. We examined the expression of IGF2, IGF1, and IGFBP-1 in zebrafish embryos treated with sodium arsenite (thought to inhibit DNA methylation), nickel chloride (thought to cause DNA hypermethylation), trichostatin A (a histone deacetylase inhibitor), 5-azaC (thought to cause methyltransferase inhibition), cadmium chloride (thought to cause DNA hypermethylation) and mercury chloride (unknown). (Abstract shortened by UMI.)
dc.format.extent	153 p.
dc.identifier.citation	Source: Masters Abstracts International, Volume: 43-06, page: 2097.
dc.identifier.uri	http://hdl.handle.net/10393/26561
dc.identifier.uri	http://dx.doi.org/10.20381/ruor-18246
dc.language.iso	en
dc.publisher	University of Ottawa (Canada)
dc.subject.classification	Biology, Molecular.
dc.title	Insulin-like growth factor-II (IGF2) gene of zebrafish and its use as a biogenetic marker for the assay of epigenetic toxin exposure
dc.type	Thesis

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