Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30
| dc.contributor.author | Dankar, Samar K | |
| dc.contributor.author | Miranda, Elena | |
| dc.contributor.author | Forbes, Nicole E | |
| dc.contributor.author | Pelchat, Martin | |
| dc.contributor.author | Tavassoli, Ali | |
| dc.contributor.author | Selman, Mohammed | |
| dc.contributor.author | Ping, Jihui | |
| dc.contributor.author | Jia, Jianjun | |
| dc.contributor.author | Brown, Earl G | |
| dc.date.accessioned | 2014-10-01T02:49:45Z | |
| dc.date.available | 2014-10-01T02:49:45Z | |
| dc.date.created | 2013 | |
| dc.date.issued | 2013 | |
| dc.description.abstract | The genetic basis for avian to mammalian host switching in influenza A virus is largely unknown. The human A/HK/156/1997 (H5N1) virus that transmitted from poultry possesses NS1 gene mutations F103L + M106I that are virulence determinants in the mouse model of pneumonia; however their individual roles have not been determined. The emergent A/Shanghai/patient1/2013(H7N9)-like viruses also possess these mutations which may contribute to their virulence and ability to switch species. | |
| dc.identifier.citation | Dankar et al. Virology Journal 2013, 10:243 | |
| dc.identifier.doi | 10.1186/1743-422X-10-243 | |
| dc.identifier.uri | http://www.virologyj.com/content/10/1/243 | |
| dc.identifier.uri | http://hdl.handle.net/10393/31675 | |
| dc.language.iso | en | |
| dc.title | Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30 | |
| dc.type | Article |
