The use of magnesium-mediated carbometallation in tandem reactions and multi-component couplings

dc.contributor.advisor	Fallis, Alex G.,
dc.contributor.author	Tessier, Pierre E
dc.date.accessioned	2013-11-07T17:24:21Z
dc.date.available	2013-11-07T17:24:21Z
dc.date.created	2003
dc.date.issued	2003
dc.degree.level	Masters
dc.degree.name	M.Sc.
dc.description.abstract	Magnesium-mediated carbometallation has been applied towards the synthesis of a variety of diverse synthetic targets. A novel carbometallation-palladium cross coupling reaction has been developed allowing for quick access to a wide variety of tetra-substituted alkenes. This methodology has been applied towards the synthesis of the anti-cancer agent (Z)-tamoxifen (66) and various analogues (82). Additional work has been done on the development of a new carbometallation-annulation reaction for the synthesis of unique bicyclic dienes based on natural chiral compounds such as camphor (124). This protocol has been employed towards the development of new chiral reagents including a chiral IBX derivative ( 119).* *Please refer to dissertation for diagrams.
dc.format.extent	125 p.
dc.identifier.citation	Source: Masters Abstracts International, Volume: 42-06, page: 2211.
dc.identifier.uri	http://hdl.handle.net/10393/26430
dc.identifier.uri	http://dx.doi.org/10.20381/ruor-18180
dc.language.iso	en
dc.publisher	University of Ottawa (Canada)
dc.subject.classification	Chemistry, Organic.
dc.title	The use of magnesium-mediated carbometallation in tandem reactions and multi-component couplings
dc.type	Thesis

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