Personalized Medicine through Automatic Extraction of Information from Medical Texts

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dc.contributor.authorFrunza, Oana Magdalena
dc.date.accessioned2012-04-17T18:56:02Z
dc.date.available2012-04-17T18:56:02Z
dc.date.created2012
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10393/22724
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-5599
dc.description.abstractThe wealth of medical-related information available today gives rise to a multidimensional source of knowledge. Research discoveries published in prestigious venues, electronic-health records data, discharge summaries, clinical notes, etc., all represent important medical information that can assist in the medical decision-making process. The challenge that comes with accessing and using such vast and diverse sources of data stands in the ability to distil and extract reliable and relevant information. Computer-based tools that use natural language processing and machine learning techniques have proven to help address such challenges. This current work proposes automatic reliable solutions for solving tasks that can help achieve a personalized-medicine, a medical practice that brings together general medical knowledge and case-specific medical information. Phenotypic medical observations, along with data coming from test results, are not enough when assessing and treating a medical case. Genetic, life-style, background and environmental data also need to be taken into account in the medical decision process. This thesis’s goal is to prove that natural language processing and machine learning techniques represent reliable solutions for solving important medical-related problems. From the numerous research problems that need to be answered when implementing personalized medicine, the scope of this thesis is restricted to four, as follows: 1. Automatic identification of obesity-related diseases by using only textual clinical data; 2. Automatic identification of relevant abstracts of published research to be used for building systematic reviews; 3. Automatic identification of gene functions based on textual data of published medical abstracts; 4. Automatic identification and classification of important medical relations between medical concepts in clinical and technical data. This thesis investigation on finding automatic solutions for achieving a personalized medicine through information identification and extraction focused on individual specific problems that can be later linked in a puzzle-building manner. A diverse representation technique that follows a divide-and-conquer methodological approach shows to be the most reliable solution for building automatic models that solve the above mentioned tasks. The methodologies that I propose are supported by in-depth research experiments and thorough discussions and conclusions.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectNatural Language Processing
dc.subjectMachine Learning
dc.subjectText Mining
dc.subjectMedical Informatics
dc.titlePersonalized Medicine through Automatic Extraction of Information from Medical Texts
dc.typeThesis
dc.faculty.departmentScience informatique et génie électrique / Electrical Engineering and Computer Science
dc.contributor.supervisorInkpen, Diana
dc.embargo.termsimmediate
dc.degree.namePhD
dc.degree.leveldoctorate
dc.degree.disciplineGénie / Engineering
thesis.degree.namePhD
thesis.degree.levelDoctoral
thesis.degree.disciplineGénie / Engineering
uottawa.departmentScience informatique et génie électrique / Electrical Engineering and Computer Science
CollectionThèses, 2011 - // Theses, 2011 -

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