Model studies for the synthesis of taxoid side-chains.

dc.contributor.advisor	Fallis, Alex G.,
dc.contributor.author	Donnelly, Ronald F.
dc.date.accessioned	2009-03-25T19:44:37Z
dc.date.available	2009-03-25T19:44:37Z
dc.date.created	1996
dc.date.issued	1996
dc.degree.level	Masters
dc.degree.name	M.Sc.
dc.description.abstract	The objectives of this thesis were to make progress toward the synthesis of the side-chain of paclitaxel. The model systems chosen were benzoyl-1,3-dithiane, (1-phenyl-2-(1,3-dithiacyclohexyl)ethanone) and hydrocinnamoyl-1,3-dithiane, (4-phenyl-1-(1,3-dithiacyclohexyl)butan-2-one). This work consisted of screening several acyl equivalents to determine which one could best be used for a one carbon homologation. Enantioselective reduction of the carbonyl group, using three different chiral reducing agents, was also studied. Studies were also conducted to determine the most efficient manner in which to unmask the carbonyl group and convert it to the more stable methyl ester. (Abstract shortened by UMI.)
dc.format.extent	118 p.
dc.identifier.citation	Source: Masters Abstracts International, Volume: 35-05, page: 1416.
dc.identifier.isbn	9780612156128
dc.identifier.uri	http://hdl.handle.net/10393/9466
dc.identifier.uri	http://dx.doi.org/10.20381/ruor-7814
dc.publisher	University of Ottawa (Canada)
dc.subject.classification	Chemistry, Organic.
dc.title	Model studies for the synthesis of taxoid side-chains.
dc.type	Thesis

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