Methods for total drug and related substances in pindolol.

dc.contributor.author	Lacroix, Pauline M.
dc.date.accessioned	2009-03-23T16:04:55Z
dc.date.available	2009-03-23T16:04:55Z
dc.date.created	1991
dc.date.issued	1991
dc.degree.level	Masters
dc.degree.name	M.Sc.
dc.description.abstract	A liquid chromatographic method for the assay of pindolol and related compounds in the bulk drug was developed. The method resolves six known and several unknown impurities from the drug and each other using a nitrile column, a mobile phase composed of acetonitrile-sodium acetate buffer (35:65), and a UV detector set at 219 nm. Minimum quantifiable amounts of impurities are 0.02% or less relative to the drug. Ten lots of pindolol raw material were evaluated for purity and drug content. Total levels of impurities in these samples, quantitated against pindolol, ranged from about 0.03% to 0.24%. Assay results were within the range of 98.5% to 101.5%.
dc.format.extent	162 p.
dc.identifier.citation	Source: Masters Abstracts International, Volume: 31-01, page: 0317.
dc.identifier.isbn	9780315680661
dc.identifier.uri	http://hdl.handle.net/10393/7885
dc.identifier.uri	http://dx.doi.org/10.20381/ruor-15547
dc.publisher	University of Ottawa (Canada)
dc.subject.classification	Chemistry, Analytical.
dc.title	Methods for total drug and related substances in pindolol.
dc.type	Thesis

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