The enigma of soluble LDLR: could inflammation be the key?

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dc.contributor.authorMbikay, Majambu
dc.contributor.authorMayne, Janice
dc.contributor.authorChrétien, Michel
dc.date.accessioned2020-02-09T04:55:14Z
dc.date.available2020-02-09T04:55:14Z
dc.date.issued2020-02-03
dc.date.updated2020-02-09T04:55:14Z
dc.description.abstractAbstract Soluble low-density lipoprotein receptor (sLDLR) is the circulating ectodomain of transmembrane LDLR. Its blood level strongly correlates with that of triglycerides (TG). This correlation has eluded satisfactory explanation. Hypertriglyceridemia and shedding of the ectodomain of many transmembrane receptors often accompany inflammatory states. The shedding mostly occurs through cleavage by a disintegrin-and-metalloproteinase-17 (ADAM-17), an enzyme activated by inflammation. It reduces the cellular uptake of TG-loaded lipoproteins, causing their accumulation in circulation; hence the correlation between plasma sLDLR and TG. Soluble LDLR could become a new surrogate marker of inflammation.
dc.identifier.citationLipids in Health and Disease. 2020 Feb 03;19(1):17
dc.identifier.urihttps://doi.org/10.1186/s12944-020-1199-9
dc.identifier.urihttps://doi.org/10.20381/ruor-24393
dc.identifier.urihttp://hdl.handle.net/10393/40159
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.titleThe enigma of soluble LDLR: could inflammation be the key?
dc.typeJournal Article

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