Buh, AmosDeonandan, RaywatGomes, JamesKrentel, AlisonOladimeji, OlanrewajuYaya, Sanni2024-02-072024-02-0720231932-6203https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295046http://hdl.handle.net/10393/45932https://doi.org/10.20381/ruor-30136The HIV/AIDS pandemic remains a significant public health issue, with sub-Saharan Africa (SSA) at its epicentre. Although antiretroviral therapy (ART) has been introduced to decrease new infections and deaths, SSA reports the highest incidence of HIV/AIDS, constituting two-thirds of the global new infections. This review aimed to elucidate the predominant barriers and facilitators influencing ART adherence and to identify effective strategies to enhance ART adherence across SSA.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultAdolescentChildHumansFemalePregnancyProspective StudiesCross-Sectional StudiesRetrospective StudiesMedication AdherenceAcquired Immunodeficiency SyndromeHIV InfectionsArticle10.1371/journal.pone.0295046