Edgar, Nicole E.Taha, HousamLy, ValentinaHatcher, Simon2025-10-272025-10-272025-10-03Harm Reduction Journal. 2025 Oct 03;22(1):159https://doi.org/10.1186/s12954-025-01311-yhttp://hdl.handle.net/10393/50969Abstract Background Stimulant use has been increasing globally over the past decade. People using drugs are now most often using both opioids and stimulants. In Canada, stimulants were involved in 68% of overdose deaths from 2020 to 2024. The overdose crisis has disproportionately impacted people experiencing homelessness. People experiencing homelessness are more likely to experience an overdose and stimulants are more likely to contribute directly to an overdose death in this population. Despite the growing need, a comprehensive and effective treatment program for people experiencing homelessness who use stimulants, that also considers trauma and safe supply options, is non-existent. We conducted a scoping review to identify the types of evidence-based treatments available to address stimulant use in people experiencing homelessness; whether any of these services were trauma-informed; and to identify knowledge gaps. Methods Using a peer-reviewed search strategy, we conducted searches in MEDLINE, Embase, PsychInfo via OVID, CINAHL, Global Health via EBSCOhost, and Scopus. Grey literature sources were hand searched. We included any primary research study with no restrictions on language or date. Reporting follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist. Results After de-duplication, 2914 titles and abstracts were screened, and 51 papers were moved to full text screening. Of this, 31 studies met eligibility criteria and were included for data extraction. Papers examined contingency management interventions (n = 20), residential treatment programs (n = 5), safer supply (n = 1), and other types of interventions (n = 4). Of the 31 papers, no studies reported using trauma-informed care approaches, although, seven incorporated some components of trauma-informed care. There was mixed evidence of effectiveness among studies, with rewards-based contingency management being generally effective and acceptable to participants. Discussion There is limited evidence available regarding stimulant use treatments for people experiencing homelessness, with most studies focusing on contingency management. Studies largely do not consider the effects of trauma in their intervention or study design. Further research is needed on harm reduction interventions such as stimulant safer supply or supervised consumption services, as well as outcomes other than abstinence that may be important to this population.Journal Article2025-10-27enThe Author(s)