Broughton, Roger,Yan, Haiyan.2009-03-232009-03-2320002000Source: Masters Abstracts International, Volume: 39-04, page: 1196.9780612571693http://hdl.handle.net/10393/9201http://dx.doi.org/10.20381/ruor-16195Excessive daytime sleepiness (EDS) is the most common presenting symptom to sleep medicine clinics and has major socio-economic consequences in industrialized societies. Several approaches have been developed to assess EDS including subjective estimates, performance effects and the rapidity of falling asleep (sleep latency) under standardized conditions, most frequently as the Multiple Sleep Latency Test (MSLT). All have definite drawbacks. It is well known, however, that the on-going EEG is sensitive to variations in alertness/sleepiness levels. This project tested the applications of quantified EEG to the detection and analysis of alertness/sleepiness levels as measured by the MSLT. Twelve age and gender matched normal subjects under rested and (one night) sleep deprived conditions and twelve sleepy untreated obstructive sleep apnea (OSA) patients underwent quantitative EEG analyses immediately before MSLT nap sessions. Mean sleep latency was significantly shorter as one compares rested controls, OSA patients and sleep-deprived controls. At both the O1 and O2 electrode sites (referential recording), the Alpha Attenuation Test (AAT) showed significantly lower AAT values as one compares rested controls, sleep-deprived controls and OSA patients. The values of absolute spectral power for the two theta bands were significantly higher in sleep deprived control subjects than in rested controls. There was an increase of absolute power spectral values for all frequency bands in OSA patients compared to rested and sleep deprived normal subjects. The significant differences between three groups in individual electrode sites were not as strong and consistent as were the total (mean of 8 electrodes) values. These results demonstrate that spectral analysis can be a sensitive measure of EDS. However, its ability to diagnose sleepiness remains uncertain. Further studies are warranted.92 p.Biology, Neuroscience.Thesis