Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions

Buchler, ArielMunch, MaximeFarber, GedaliahZhao, XiaolingAl-Haddad, RamiFarber, EadanRotstein, Benjamin H2022-08-262022-08-2720221536-1632http://link.springer.com/article/10.1007/s11307-021-01626-9http://hdl.handle.net/10393/43964https://doi.org/10.20381/ruor-28177Overexpression and activation of matrix metalloproteinase-13 (MMP-13) within atheroma increases susceptibility to plaque rupture, a major cause of severe cardiovascular complications. In comparison to pan-MMP targeting [18F]BR-351, we evaluated the potential for [18F]FMBP, a selective PET radiotracer for MMP-13, to detect extracellular matrix (ECM) remodeling in vascular plaques possessing markers of inflammation.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/AtherosclerosisAutoradiographyInflammationMatrix metalloproteinasesPositron emission tomographyRadiotracerRemodelingVulnerable plaquesAnimalsExtracellular MatrixMatrix Metalloproteinase 13MiceTissue DistributionAtherosclerosisPlaque, AtheroscleroticSelective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic LesionsArticle10.1007/s11307-021-01626-9