Rahmouni El Idrissi, Kenza2025-08-012025-08-012025-08-01http://hdl.handle.net/10393/50720https://doi.org/10.20381/ruor-31294Surgical outcomes for ischemic mitral regurgitation (IMR) in females compared to males remain unclear. The goal of this thesis was to assess sex-based outcomes in patients undergoing surgery for chronic IMR through two distinct projects. First, the IMR literature was reviewed through a systematic review and meta-analysis to compare surgical outcomes of mitral valve surgery for IMR in females and males. There were no significant sex-based differences in long-term and operative mortality, heart failure rehospitalization and mitral reinterventions, but females had higher rates of MR recurrence than males. Second, a cohort study with 1086 patients (30.4% females) with IMR was conducted. In this cohort, after inverse-probability of treatment weighting and multivariate adjustment, all-cause 30-day mortality was higher in females, but long-term mortality was similar between sexes. This thesis further supports the need for inclusion of more females in cardiovascular research and for systematic reporting of sex- and gender-specific data.enSex-Based AnalysisIschemic Heart DiseaseMitral Valve InsufficiencyMitral Valve SurgeryWomen's Heart HealthCardiac SurgeryThesis