McLellan, AndrewKabir, MonishaLacombe, CorinaKhorsand, SohaGeller, CarolBair, LissaEyre, Alison2026-06-022026-06-022026-04-18BMC Primary Care. 2026 Apr 18;27(1):211https://doi.org/10.1186/s12875-026-03304-7http://hdl.handle.net/10393/51728Abstract Background Urban marginalised populations face intersecting barriers, such as poverty, unstable housing and discrimination, that erode health literacy in primary-care contexts. We examined whether an inter-professional, low-barrier primary care model improves health literacy competencies compared with usual care. Methods A convergent mixed-methods study took place at Centretown Community Health Centre (CCHC), Ottawa (2019–2023). Phase 1 compared Health Literacy Questionnaire (HLQ) scores between clients receiving tailored care (n = 37) and matched community members using usual services (n = 36). Phase 2 explored experiences through four focus groups and semi-structured interviews (n = 23). Independent samples t-tests and inductive thematic analysis were used. Results Overall health literacy was moderate in both groups; however, the tailored-care group scored higher on appraisal of health information (M = 3.03 ± 0.57 vs. 2.76 ± 0.46, p = 0.025, d = 0.53). Qualitatively, tailored-care participants described clearer chronic-disease self-management, strategic navigation of appointments, and fewer inappropriate emergency department visits. Persistently low social support scores highlighted systemic isolation. Conclusions Embedding social supports, outreach, and client-centred education within primary care can strengthen critical appraisal skills in marginalised settings. Scaling such models should pair literacy interventions with broader community-support strategies. Trial registration Not applicable (observational study).Journal Article2026-06-02enThe Author(s)