Houston, Adam RBeall, Reed FAttaran, Amir2016-05-182016-05-182016-05-02Journal of Pharmaceutical Policy and Practice. 2016 May 02;9(1):15http://dx.doi.org/10.1186/s40545-016-0064-8http://hdl.handle.net/10393/34725Abstract Exorbitant price increases for critical off-patent medicines have received considerable media attention in recent months, leading to an investigation by the U.S. Senate. However, much of this attention has focused upon the companies that initiated the price increases, all of whom had recently acquired the drugs in question. Overlooked are upstream interventions with the originators of these drugs to prevent generics trolling in the first place. Using the particular example of Eli Lilly and Company’s efforts to divest itself of cycloserine, a flawed process that paved the way for the recent price hike by Rodelis Therapeutics, this article highlights the responsibilities of drug originators, and safeguards to ensure similar rights transfers do not affect ongoing affordable access.2016-05-18enHouston et al.