Baker, LauraShaw, JosephKhair, SimonneBryson, GregoryFergusson, DeanKelly, ErinLeGal, GregoireMartel, GuillaumeTinmouth, AllanSaidenberg, Elianna2019-02-042019-02-042019http://hdl.handle.net/10393/38788https://doi.org/10.20381/ruor-23040Introduction: Patients with coagulation abnormalities requiring invasive procedures are commonly encountered. Such abnormalities may arise as a consequence of congenital or acquired deficiencies of platelets or coagulation factors or the use of anti-platelet or anti-coagulant medications. The availability and quality of guidelines pertaining to specific procedures and patient populations and their quality has yet to be surveyed. Objective: The purpose of this review is to evaluate and summarize existing guidelines for the management of patients with abnormal coagulation undergoing invasive procedures. Methods & Analysis: A scoping review will be conducted to identify guidelines pertaining to patients with abnormalities of hemostasis undergoing invasive procedures. EMBASE and Medline will be systematically searched from January 1998 to present. The following guideline-specific databases will also be searched: National Institute for Health and Care Excellence (NICE) (UK), the Canadian Medical Association Infobase (Canada), the G-I-N International Guideline Library, the New Zealand Guidelines (NZG) Group, The World Health Organization and the Scottish Intercollegiate Guidelines Network (SIGN). Title and abstract screening will be performed in duplicate by two reviewers. Full manuscript review and data abstraction will be performed independently in duplicate. References of included articles will also be scanned for potentially relevant publications. The following data will be extracted from eligible guidelines: specified patient population, planned procedure and recommended peri-procedural management of coagulation abnormality (timing and details of medication cessation and initiation, administration of blood products, anticoagulant reversing agents or pro-hemostatic agents). The Appraisal of Guidelines for Research & Evaluation (AGREE) II tool will be used to evaluate the methodological quality of identified guidelines. Results will be presented through (1) a descriptive summary of studies and (2) a summary of available guidelines and their associated quality. A multidisciplinary group of experts has been involved in the development of this protocol and will be involved throughout the conduct of this study. Ethics & Dissemination: This study aims to investigate and summarize previously published guidelines and therefore does not require ethics approval. This review will allow for appreciation of available literature on the topic, helping to identify gaps and inform future research. Additionally, it will serve as a valuable resource to health care providers managing patients with coagulation abnormalities requiring invasive procedures. We intend to report the findings of this scoping review in a peer-reviewed journal and at a scientific conference. Registration: Submitted to University of Ottawa Library Depository Keywords:encoagulation abnormalityinterventionbleeding disorderprocedureguidelineResearch Paper