Tsertsvadze, Alexander2013-11-072013-11-0720042004Source: Masters Abstracts International, Volume: 43-06, page: 2218.http://hdl.handle.net/10393/26787http://dx.doi.org/10.20381/ruor-18370Bladder cancer is the second most frequently diagnosed neoplasm of the urinary tract. Effects of physical activity and body fat mass on risk of bladder cancer are not well studied. Physical activity and/or body weight may exert their effects on bladder cancer risk through hormonal, immune, or yet other unknown causal pathways. This thesis, using a case-control study design, investigated the association between recreational physical activity, relative body weight (BMI), and risk of bladder cancer in men and women separately. The analysis was based on a portion of the National Enhanced Cancer Surveillance System dataset. The self-reported data had been collected from bladder cancer cases and population controls during 1994--1997 in seven Canadian Provinces. The analyzed samples were 2,312 males (670 cases and 1,642 controls) and 1,824 women (359 cases and 1,465 controls). In men and women, the adjusted ORs (highest vs. lowest quartile) for physical activity were 1.24 (95% CI: 0.93, 1.66) and 0.76 (95% CI: 0.52, 1.21), respectively. The corresponding ORs for BMI were 1.29 (95% CI: 0.96, 1.72) and 1.07 (95% CI: 0.74, 1.55), respectively. This study found that parous women were at reduced risk of bladder cancer compared to nulliparous women (OR = 0.56. 95% confidence interval: 0.39, 0.80). In agreement with other studies, certain occupations and cigarette smoking were associated with increased risk of bladder cancer. In men, but not in women, coffee consumption was associated with a slightly increased risk of bladder cancer (≥1 cup per day vs. never: OR = 1.30, 95% CI: 1.00, 1.68). There was not enough evidence in this study to conclude that recreational physical activity and BMI were related to risk of bladder cancer.169 p.enHealth Sciences, Public Health.Health Sciences, Oncology.Thesis