Djafarzadeh, Roxana2013-11-072013-11-0720052005Source: Masters Abstracts International, Volume: 44-04, page: 1925.http://hdl.handle.net/10393/26890http://dx.doi.org/10.20381/ruor-11813It is the intent of this thesis to investigate and develop a simulation model for metabolic pathways in the cells, namely, Glycolysis and Krebs cycle, using the DEVS formalism and the CD++ tool, then to further improve it to complete virtual mitochondrion. The hierarchical nature of DEVS makes it ideal for describing naturally hierarchical systems as the Cell, while its discrete-event approach improves performance due to the asynchronous nature of the events occurring in the cell. Simultaneously, as DEVS is a timed-based modeling approach, timing of the chemical reactions can be adequately represented. The models were developed using the CD++ toolkit, a modeling tool for simulation of complex physical systems that can be used to simulate a variety of models. CD++ server permits the execution and visualization of the results with sophisticated and easy-to-use Graphical User Interfaces. A precise and easy to use simulation environment for biological models of glycolysis and Krebs cycle was created, and the results presented show the potential of this approach.216 p.enEngineering, Electronics and Electrical.Thesis