2026-09-23T17:39:46Zhttps://ruor.uottawa.ca/server/oai/request

oai:ruor.uottawa.ca:10393/407372024-02-23T08:57:35Zcom_10393_242col_10393_11105

Risk Factors, Mechanisms and Therapeuthic for Right Heart Failure Associated with Pulmonary Hypertension Zelt, Jason Mielniczuk, Lisa Marie Beanlands, Rob Right Heart Failure Pulmonary Hypertension Adenylate Kinase Metabolism Sympathetic Nervous System Positron Emission Tomography Right ventricular function (RV) is one of the most important predictors of prognosis in many cardiovascular disease states. Despite the significance of RV function to survival, there are no therapies that directly nor selectively improve RV function. As well, the basis for RV failure is poorly understood. This is particularly relevant for patients with pulmonary arterial hypertension (PAH), where RV failure in the setting of pressure overload is the leading cause of death. PAH will be introduced in the 2nd chapter of this thesis by comparing and refining contemporary mortality risk assessment strategies. I will then explore 1) RV neurohormonal function and, 2) RV energetics, two molecular pathways thought to be involved in the pathogenesis and progression of maladaptive RV failure. I employed small animal molecular imaging using positron emission tomography (PET) to non-invasively investigate these pathways. The PET imaging techniques employed in this thesis have the unique potential for translation to human studies, to further explore disease mechanisms. 2020-07-16T18:24:55Z 2021-01-16T10:00:07Z 2020-07-16 Thesis http://hdl.handle.net/10393/40737 http://dx.doi.org/10.20381/ruor-24965 en application/pdf Université d'Ottawa / University of Ottawa