2026-09-22T17:39:45Zhttps://ruor.uottawa.ca/server/oai/request

oai:ruor.uottawa.ca:10393/367252024-02-23T08:54:06Zcom_10393_242col_10393_11105

Dubé, Chantal Bainbridge-Whiteside, Shannon Adamo, Kristi Bree 2017-10-02T13:22:45Z 2019-10-02T09:00:08Z 2017 http://hdl.handle.net/10393/36725 http://dx.doi.org/10.20381/ruor-21005 Background: Exercise in pregnancy is associated with optimized fetal growth; however, the implicated mechanisms remain unknown. We hypothesize that exercise-induced myokines may be acting on the placenta to optimize fetal growth across gestation. Methodology: 1) Circulating profiles of 11 myokines were analyzed in 2nd trimester plasma of women characterized as active (N=14) or non-active (N=16) during pregnancy. 2) First trimester human placental explants (N=5) were treated with SPARC in a dose-dependent manner (0-150ng/ml). Metrics of placental health/function, including GLUT-4 expression/regulation, were assessed. Results: 1) Active women demonstrated an elevation in circulating SPARC compared to non-active women (86±19pg/ml vs. 52±18pg/ml, p=0.0001). 2) Explants treated with SPARC at 100ng/ml demonstrated improved invasion, with improved maximum outgrowth distance (N=3; p=0.0219). Conclusion: SPARC is a myokine that is elevated in the circulation of active pregnant women and is associated with improved placental invasion, suggesting a possible role of SPARC in placentation. en Université d'Ottawa / University of Ottawa placenta exercise pregnancy skeletal muscle myokines The Effect of Exercise-induced Myokines on Placental Health and Function Thesis 2019-10-02 00:00:00 MSc Masters Sciences de la santé / Health Sciences Santé des populations / Population Health open.access