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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory Saldanha, Marsha Biology, Microbiology. Health Sciences, Immunology. CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell activation, and Listeria monocytogenes (LM) which induces massive T cell activation, the influence of T cell stimulation on memory development was discerned. It was hypothesized that muted activation of CD8+ T cells by BCG might result in impaired development of memory. It was found that in contrast to LM naive as well as memory CD8+ T cells undergo delayed and muted expansion and contraction during BCG infection. Memory CD8+ T cells remained functional as they expressed cytokines, killed targets and proliferated in response to antigen. Furthermore, inflammatory cytokines and T cells curtail antigen-presentation during BCG infection which curbs T cell stimulation and favors the development of functional memory. 2013-11-07T19:02:56Z 2013-11-07T19:02:56Z 2007 2007 Thesis Source: Masters Abstracts International, Volume: 47-06, page: 3415. http://hdl.handle.net/10393/27915 http://dx.doi.org/10.20381/ruor-18979 en 148 p. application/pdf University of Ottawa (Canada)