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oai:ruor.uottawa.ca:10393/205302024-02-23T09:07:20Zcom_10393_242col_10393_11105

Investigation of the Effects of Genistein and Fenretinide on Ovarian Cancer Cells Azadi, Behnam Vanderhyden, Barbara Kubow, Stan Ein: Genistein Fen: Fenretinide SM: Soy Milk The effects of the fenretinide and genistein as single or combined drugs on ovarian cancer proliferation and viability were investigated. Hypothesis: Co-treatment with genistein will enable a lower dose of fenretinide to be effective in inhibiting the proliferation and survival of ovarian cancer cells. Methods: Low and high doses of genistein and fenretinide were tested on A2780s and A2780cp cells using trypan blue viable cell count, MTS assay. Results and conclusions: Unlike low doses of fenretinide, genistein had anti-proliferative effects on both cell lines. There were no additive or synergistic effects of the two compounds. Higher dose treatments induced anti-proliferative effects and apoptotic cell death in both A2780s and A2780cp cells, with a greater sensitivity of A2780s cells to both test compounds. Overall Conclusion: Genistein and higher doses of fenretinide similarly impair cell cycle progression and induce apoptosis. The anti-proliferative effects of genistein can be affected by co-treatment with fenretinide 2012-01-10T18:10:55Z 2012-01-10T18:10:55Z 2012 2012 Thesis http://hdl.handle.net/10393/20530 http://dx.doi.org/10.20381/ruor-5144 en application/pdf Université d'Ottawa / University of Ottawa