Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions

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Title: Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions
Authors: Buchler, Ariel
Munch, Maxime
Farber, Gedaliah
Zhao, Xiaoling
Al-Haddad, Rami
Farber, Eadan
Rotstein, Benjamin H
Date: 2022
Abstract: Overexpression and activation of matrix metalloproteinase-13 (MMP-13) within atheroma increases susceptibility to plaque rupture, a major cause of severe cardiovascular complications. In comparison to pan-MMP targeting [18F]BR-351, we evaluated the potential for [18F]FMBP, a selective PET radiotracer for MMP-13, to detect extracellular matrix (ECM) remodeling in vascular plaques¬†possessing markers of inflammation.
URL: http://link.springer.com/article/10.1007/s11307-021-01626-9
http://hdl.handle.net/10393/43964
DOI: 10.1007/s11307-021-01626-9
CollectionBiochimie, microbiologie et immunologie // Biochemistry, Microbiology and Immunology
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