Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C-carbonyls

Description
Title: Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C-carbonyls
Authors: Ismailani, Uzair S
Munch, Maxime
Mair, Braeden A
Rotstein, Benjamin H
Date: 2021
Abstract: A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [11C]URB694 and [11C]glibenclamide.
URL: http://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc01016f
http://hdl.handle.net/10393/43963
DOI: 10.1039/d1cc01016f
CollectionBiochimie, microbiologie et immunologie // Biochemistry, Microbiology and Immunology
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Ismailani et al IMP CO2 CC 2021.pdfManuscript accepted version542.25 kBAdobe PDFOpen
Ismailani et al IMP CO2 CC 2021 SI.pdfSupplement2.6 MBAdobe PDFOpen


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