Aging attenuates purinergic, but not muscarinic and nicotinic, cutaneous vasodilation in men

Title: Aging attenuates purinergic, but not muscarinic and nicotinic, cutaneous vasodilation in men
Authors: Fujii, Naoto
Nishiyasu, Takeshi
Sigal, Ronald
Boulay, Pierre
McGarr, Gregory
Kenny, Glen
Date: 2018
Abstract: Objective: We evaluated the hypothesis that aging attenuates muscarinic, nicotinic, and purinergic receptor related cutaneous vasodilation. Methods: In 11 young (24±4 years) and 11 older males (61±8 years), cutaneous vascular conductance (CVC) was assessed at three forearm skin sites that were infused with either: 1) methacholine (muscarinic receptor agonist, 5 doses: 0.0125, 0.25, 5, 100, 2000 mM), 2) nicotine (nicotinic receptor agonist, 5 doses: 1.2, 3.6, 11, 33, 100 mM), or 3) adenosine triphosphate (ATP) (purinergic receptor agonist, 5 doses: 0.03, 0.3, 3, 30, 300 mM). Each agonist was administered for 25 min per dose. Results: We showed that CVC at all doses of methacholine did not differ between groups. Similarly, no between-group differences in CVC were observed during nicotine administration at all doses administered. By contrast, while no differences in CVC were measured during the administration of ATP at low (0.03 and 0.3 mM) or high (300 mM) concentrations, CVC was reduced in the older relative to the young males at moderate concentrations of ATP (3mM:23±6 vs. 40±13%max, 30 mM:62 ± 11 vs. 83 ± 8%max, both P≤0.05). Conclusions: We show that aging attenuates purinergic, but not muscarinic or nicotinic, cutaneous vasodilation in men.
DOI: 10.1111/micc.12462
CollectionSciences de la santé - Publications // Health Sciences - Publications
Fujii et al Aging regulation cutaneous vasodilation Microcirculation 2018.pdfpre-peer reviewed version of the following article: Aging attenuates adenosine triphosphate‐induced, but not muscarinic and nicotinic, cutaneous vasodilation in men,Microcirculation. 2018 Jul;25(5):e12462. doi: 10.1111/micc.12462. Epub 2018 Jun 19, which has been published in final form at kBAdobe PDFOpen