Roles of MicroRNA across Prenatal and Postnatal Periods

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dc.contributor.authorFloris, Ilaria
dc.contributor.authorKraft, Jamie
dc.contributor.authorAltosaar, Illimar
dc.date.accessioned2019-03-28T15:28:10Z
dc.date.available2019-03-28T15:28:10Z
dc.date.issued2016
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10393/38994
dc.description.abstractCommunication between mother and offspring in mammals starts at implantation via the maternal-placental-fetal axis, and continues postpartum via milk targeted to the intestinal mucosa. MicroRNAs (miRNAs), short, noncoding single-stranded RNAs, of about 22 nucleotides in length, are actively involved in many developmental and physiological processes. Here we highlight the role of miRNA in the dynamic signaling that guides infant development, starting from implantation of conceptus and persisting through the prenatal and postnatal periods. miRNAs in body fluids, particularly in amniotic fluid, umbilical cord blood, and breast milk may offer new opportunities to investigate physiological and/or pathological molecular mechanisms that portend to open novel research avenues for the identification of noninvasive biomarkers.
dc.language.isoen
dc.subjectbreast milk
dc.subjectmaternal-offspring crosstalk
dc.subjectmicroRNA
dc.subjectnoninvasive biomarkers
dc.subjectAmniotic Fluid
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectEmbryo Implantation
dc.subjectFemale
dc.subjectHumans
dc.subjectMicroRNAs
dc.subjectMilk, Human
dc.subjectPregnancy
dc.titleRoles of MicroRNA across Prenatal and Postnatal Periods
dc.typeArticle
dc.identifier.doi10.3390/ijms17121994
CollectionPublications en libre accès financées par uOttawa // uOttawa financed open access publications

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