Lycopene: A Potential Prostate Cancer Fighting Antioxidant – A structured review

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Title: Lycopene: A Potential Prostate Cancer Fighting Antioxidant – A structured review
Authors: Gagnon, Stephanie
Liimatainen, Krista
Li, Shuangxi
Date: 2017-12-01
Abstract: Prostate cancer is currently the second leading cause of cancer mortality in men in the United States1. It is found to be the most common type of cancer making it a major research topic2. Some studies have found significant associations between dietary factors and prostate cancer, such as lycopene, a carotenoid antioxidant naturally found in abundance in tomato products3. In order to better understand this association, a structured literature review was conducted using the appropriate means and methods. The research review that is being presented aims at answering whether or not lycopene is a potential prostate cancer fighting antioxidant. The articles for this review were chosen from JNCI, PubMed, and AACR databases whereby the search was primarily narrowed down by keywords: lycopene, tomato product, prostate cancer, prevention, carotene, and nutrition. The search was limited to English and access to full texts, and excluded other reviews. Articles were further evaluated based on the relevance of their titles and abstracts. The correlation between lycopene and prostate cancer varied among the different studies and uptake mechanisms (injection versus consumption). Five of the eight studies used in this review deemed lycopene effective in lowering the risk of prostate cancer, while the remaining showed no significant associations. One study showed an inverse association between tomato products and prostate cancer (rather than lycopene alone), which questions whether or not lycopene is the effective agent in fighting prostate cancer, or if a more complicated process is required. Due to the limitations, biases and the varied results encountered in the studies reviewed, it is unclear that whether or not lycopene is an effective antioxidant in fighting prostate cancer in men. Future studies should focus on lycopene uptake mechanisms. In order to present a more formal and conclusive answer, more controlled and reproducible research should be done.
URL: http://hdl.handle.net/10393/36985
CollectionSciences de la santé - Affiches // Health Sciences - Research Posters
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