Associations Between Variants in the NF- κB1 Gene, Alone or in Combination with Saturated Fats, and Anthropometric Traits in Young Adults

FieldValue
dc.contributor.authorBauman-Fortin, Jeremy
dc.date.accessioned2017-01-30T14:49:54Z
dc.date.available2017-01-30T14:49:54Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/10393/35782
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-2651
dc.description.abstractAnimal studies have shown that chronic high consumption of saturated fat (SF) leads to hypothalamic inflammation and ultimately, alters appetite control. This has been shown to be partly due to an increase in the activity of the transcription factor Nuclear Factor-κB (NF-κB), a major regulator of the inflammatory response. The goal of the study was to first confirm the association between SF measurements and anthropometric traits, then to determine the association between single nucleotide polymorphisms (SNPs) in the NF-κB1 gene and body mass index (BMI) and waist circumference (WC), and finally, to test the interaction between variants in this gene and dietary SF and circulating saturated fatty acids (CSFA) on these anthropometric traits in young adults. A significant positive association was identified between quartiles of CSFA and anthropometric measurements in the total sample (BMI: p = 0.0003, WC: p = 0.0001) and in South Asians (BMI: p = 0.004, WC: p = 0.01), but only marginally among Caucasians (BMI: p = 0.08, WC: p = 0.051) and East Asians (BMI: p = 0.13, WC: p = 0.053). After correcting for false discovery rate, carriers of the T allele in SNP rs4648022 had higher BMI and WC compared to those with the dominant CC genotype (p = 0.0003 and p = 0.0001, respectively). Among Caucasians, there was a significant interaction between SNPs in the NF-κB1 gene and quartiles of CSFA on WC for rs4648095 (p = 0.002). Thus, certain SNPs in the NF-κB1 gene appear to influence BMI and WC and also to modify the association between CSFA and anthropometric traits.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectNutrigenetics
dc.subjectSaturated fat
dc.subjectNF-κB
dc.subjectGene-diet interaction
dc.subjectObesity
dc.titleAssociations Between Variants in the NF- κB1 Gene, Alone or in Combination with Saturated Fats, and Anthropometric Traits in Young Adults
dc.typeThesis
dc.contributor.supervisorFontaine-Bisson, Bénédicte
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineSciences de la santé / Health Sciences
uottawa.departmentSciences de l'activité physique / Human Kinetics
CollectionThèses, 2011 - // Theses, 2011 -

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