Tissue photo-bonding using biopolymer crosslinked with rose bengal

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dc.contributor.authorPupkaite, Justina
dc.contributor.authorTemkit, Maha
dc.contributor.authorKochevar, Irene
dc.contributor.authorSuuronen, Erik
dc.contributor.authorAlarcon, Emilio
dc.contributor.authorGriffith, May
dc.date.accessioned2016-12-14T19:20:32Z
dc.date.available2016-12-14T19:20:32Z
dc.date.issued2016
dc.identifier.citationEuropean Cells and Materials Vol. 31. Suppl. 1, 2016 (page p385)
dc.identifier.issn1473-2262
dc.identifier.urihttp://www.ecmjournal.org/journal/supplements/vol031supp01/pdf_posters/Vol031Supp01P385.pdf
dc.identifier.urihttp://hdl.handle.net/10393/35606
dc.description.abstractVisible light-activated photobonding of tissues presents an attractive alternative to surgical suturing for closing of dermal wounds. The advantages of photo-bonding include reduced inflammation and less scarring. However, the materials currently used for light-activated wound closure allow for only a limited, if any, ability to modulate the biological and mechanical properties of the resulting bonded tissue. Particularly, the micrometric void within dermal wounds presents another obstacle for the photo-bonding materials, since collagen structures are required for the photobonding to occur. Therefore, developing a light-activated biomaterial glue that can overcome these limitations would represent an important advance in translational potential. To this end, we have developed a new generation of photo-bonding materials based on vinyl-modified collagen and rose Bengal that are crosslinkable using visible light.
dc.description.sponsorshipThis work was funded by an operating grant from Vetenskapsradet to MG, a Burroughs Wellcome Fund Travel Grant Program to EIA and IK, and by Discovery Grants #342107 to EJS and RGPIN- 2015-06325 to EIA from the Natural Sciences and Engineering Research Council.
dc.language.isoen
dc.subjectphotobonding
dc.subjectdermal wounds
dc.subjectcrosslinked
dc.subjectcollagen
dc.subjectlight-activated
dc.subjectbiomaterial glue
dc.subjectrose Bengal
dc.subjectbiopolymer
dc.titleTissue photo-bonding using biopolymer crosslinked with rose bengal
dc.typeArticle
CollectionICUO - Publications // UOHI - Publications

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