Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity

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dc.contributor.authorRajkumar, Abishankari
dc.contributor.authorLamothe, Gilles
dc.contributor.authorBolongo, Pierrette
dc.contributor.authorHarper, Mary-Ellen
dc.contributor.authorAdamo, Kristi
dc.contributor.authorDoucet, Éric
dc.contributor.authorRabasa-Lhoret, Remi
dc.contributor.authorPrud’homme, Denis
dc.contributor.authorTesson, Frédérique
dc.date.accessioned2016-11-21T16:13:13Z
dc.date.available2016-11-21T16:13:13Z
dc.date.issued2016-08-11
dc.identifier.citationBMC Medical Genetics. 2016 Aug 11;17(1):56
dc.identifier.urihttp://dx.doi.org/10.1186/s12881-016-0320-4
dc.identifier.urihttp://hdl.handle.net/10393/35425
dc.description.abstractAbstract Background Genetic studies on Acyl-CoA Synthetase Long-Chain 5 (ACSL5) demonstrate an association between rs2419621 genotype and rate of weight loss in women with obesity in response to caloric restriction. Our objectives were to (1) confirm results in two different populations of women with overweight and obesity (2) study rs2419621’s influence on body composition parameters of women with overweight and obesity following lifestyle interventions. Methods rs2419621 genotype was determined in women with overweight and obesity who participated in the Montréal-Ottawa New Emerging Team (MONET n = 137) and Complications Associated with Obesity (CAO n = 37) studies. Genotyping was done using TaqMan MGB probe-based assay. Multiple linear regression analyses were used to test for associations. Results When studying women with overweight and obesity, rs2419621 [T] allele carriers had a significantly greater decrease in visceral fat, absolute and percent fat mass and a greater increase in percent lean mass in response to lifestyle intervention in comparison to non-carriers. Studying only individuals with obesity showed similar results with rs2419621 [T] allele carriers also displaying a significantly greater decrease in body mass index following the lifestyle intervention in comparison to non-carriers. Conclusion Women with overweight and obesity carrying the ACSL5 rs2419621 [T] allele are more responsive to lifestyle interventions in comparison to non-carriers. Conducting such genetic association studies can aid in individualized treatments/interventions catered towards an individual’s genotype.
dc.titleAcyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity
dc.typeJournal Article
dc.date.updated2016-11-21T16:13:13Z
dc.language.rfc3066en
dc.rights.holderThe Author(s).
CollectionLibre accès - Publications // Open Access - Publications

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