Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)

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Title: Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)
Authors: Chow, Benjamin J
Green, Rachel E
Coyle, Doug
Laine, Mika
Hanninen, Helena
Leskinen, Hanna
Rajda, Miroslav
Larose, Eric
Hartikainen, Juha
Hedman, Marja
Mielniczuk, Lisa
O’Meara, Eileen
deKemp, Robert A
Klein, Ran
Paterson, Ian
White, James A
Yla-Herttuala, Seppo
Leber, Alex
Tandon, Vikas
Lee, Ting
Al-Hesayen, Abdul
Hessian, Renee
Dowsley, Taylor
Kass, Malek
Kelly, Cathy
Garrard, Linda
Tardif, Jean-Claude
Knuuti, Juhani
Beanlands, Rob S
Wells, George A
Date: 2013-12-26
Abstract: Abstract Background The prevalence of heart failure (HF) is rising in industrialized and developing countries. Though invasive coronary angiography (ICA) remains the gold standard for anatomical assessment of coronary artery disease in HF patients, alternatives are being sought. Computed tomographic coronary angiography (CTA) has emerged as an accurate non-invasive diagnostic tool for coronary artery disease (CAD) and has been demonstrated to have prognostic value. Whether or not CTA can be used in HF patients is unknown. Acknowledging the aging population, the growing prevalence of HF and the increasing financial burden of healthcare, we need to identify non-invasive diagnostic tests that are available, safe, accurate and cost-effective. Methods/Design The proposed study aims to provide insight into the efficacy of CTA in HF patients. A multicenter randomized controlled trial will enroll 250 HF patients requiring coronary anatomical definition. Enrolled patients will be randomized to either CTA or ICA (n = 125 per group) as the first test to define coronary anatomy. The primary outcomes will be collected to determine downstream resource utilization. Secondary outcomes will include the composite clinical events and major adverse cardiac events. In addition, the accuracy of CTA for detecting coronary anatomy and obstruction will be assessed in patients who subsequently undergo both CTA and ICA. It is expected that CTA will be a more cost-effective strategy for diagnosis: yielding similar outcomes with fewer procedural risks and improved resource utilization. Trial registration ClinicalTrials.gov,NCT01283659 Team grant #CIF 99470
URL: http://dx.doi.org/10.1186/1745-6215-14-443
http://hdl.handle.net/10393/33843
CollectionLibre accès - Publications // Open Access - Publications
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