Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies

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dc.contributor.authorRaimondi, Sara
dc.contributor.authorGandini, Sara
dc.contributor.authorFargnoli, Maria C
dc.contributor.authorBagnardi, Vincenzo
dc.contributor.authorMaisonneuve, Patrick
dc.contributor.authorSpecchia, Claudia
dc.contributor.authorKumar, Rajiv
dc.contributor.authorNagore, Eduardo
dc.contributor.authorHan, Jiali
dc.contributor.authorHansson, Johan
dc.contributor.authorKanetsky, Peter A
dc.contributor.authorGhiorzo, Paola
dc.contributor.authorGruis, Nelleke A
dc.contributor.authorDwyer, Terry
dc.contributor.authorBlizzard, Leigh
dc.contributor.authorFernandez-de-Misa, Ricardo
dc.contributor.authorBranicki, Wojciech
dc.contributor.authorDebniak, Tadeusz
dc.contributor.authorMorling, Niels
dc.contributor.authorLandi, Maria T
dc.contributor.authorPalmieri, Giuseppe
dc.contributor.authorRibas, Gloria
dc.contributor.authorStratigos, Alexander
dc.contributor.authorCornelius, Lynn
dc.contributor.authorMotokawa, Tomonori
dc.contributor.authorAnno, Sumiko
dc.contributor.authorHelsing, Per
dc.contributor.authorWong, Terence H
dc.contributor.authorAutier, Philippe
dc.contributor.authorGarcía-Borrón, José C
dc.contributor.authorLittle, Julian
dc.contributor.authorNewton-Bishop, Julia
dc.contributor.authorSera, Francesco
dc.contributor.authorLiu, Fan
dc.contributor.authorKayser, Manfred
dc.contributor.authorNijsten, Tamar
dc.date.accessioned2015-12-18T10:53:51Z
dc.date.available2015-12-18T10:53:51Z
dc.date.issued2012-08-03
dc.identifier.citationBMC Medical Research Methodology. 2012 Aug 03;12(1):116
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2288-12-116
dc.identifier.urihttp://hdl.handle.net/10393/33600
dc.description.abstractAbstract Background For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a disease. Pooled-analysis of epidemiological studies has many advantages over meta-analysis, and preliminary results may be obtained faster and with lower costs than with prospective consortia. Design and methods Based on our experience with the study design of the Melanocortin-1 receptor (MC1R) gene, SKin cancer and Phenotypic characteristics (M-SKIP) project, we describe the most important steps in planning and conducting a pooled-analysis of genetic epidemiological studies. We then present the statistical analysis plan that we are going to apply, giving particular attention to methods of analysis recently proposed to account for between-study heterogeneity and to explore the joint contribution of genetic, phenotypic and environmental factors in the development of a disease. Within the M-SKIP project, data on 10,959 skin cancer cases and 14,785 controls from 31 international investigators were checked for quality and recoded for standardization. We first proposed to fit the aggregated data with random-effects logistic regression models. However, for the M-SKIP project, a two-stage analysis will be preferred to overcome the problem regarding the availability of different study covariates. The joint contribution of MC1R variants and phenotypic characteristics to skin cancer development will be studied via logic regression modeling. Discussion Methodological guidelines to correctly design and conduct pooled-analyses are needed to facilitate application of such methods, thus providing a better summary of the actual findings on specific fields.
dc.titleMelanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies
dc.typeJournal Article
dc.date.updated2015-12-18T10:53:51Z
dc.language.rfc3066en
dc.rights.holderRaimondi et al.; licensee BioMed Central Ltd.
CollectionLibre accès - Publications // Open Access - Publications

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