Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group

dc.contributor.authorCellot, Sonia
dc.contributor.authorJohnston, Donna
dc.contributor.authorDix, David
dc.contributor.authorEthier, Marie-Chantal
dc.contributor.authorGillmeister, Biljana
dc.contributor.authorMitchell, David
dc.contributor.authorYanofsky, Rochelle
dc.contributor.authorLewis, Victor
dc.contributor.authorPortwine, Carol
dc.contributor.authorPrice, Victoria
dc.contributor.authorZelcer, Shayna
dc.contributor.authorSilva, Mariana
dc.contributor.authorBowes, Lynette
dc.contributor.authorMichon, Bruno
dc.contributor.authorStobart, Kent
dc.contributor.authorBrossard, Josee
dc.contributor.authorBeyene, Joseph
dc.contributor.authorSung, Lillian
dc.identifier.citationBMC Cancer. 2013 Jun 04;13(1):276
dc.description.abstractAbstract Background It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly diagnosed APL and to describe factors associated with these infections. Methods We conducted a retrospective, population-based cohort study that included children ≤ 18 years of age with de novo APL treated at 15 Canadian centers. Thirty-three children with APL were included; 78.8% were treated with APL -specific protocols. Results Bacterial sterile site infection occurred in 12 (36.4%) and fungal sterile site infection occurred in 2 (6.1%) children. Of the 127 chemotherapy courses, 101 (79.5%) were classified as intensive and among these, the proportion in which a sterile site microbiologically documented infection occurred was 14/101 (13.9%). There was one infection-related death. Conclusions One third of children with APL experienced at least one sterile site bacterial infection throughout treatment and 14% of intensive chemotherapy courses were associated with a microbiologically documented sterile site infection. Infection rates in pediatric APL may be lower compared to non- APL acute myeloid leukemia although these children may still benefit from aggressive supportive care during intensive chemotherapy.
dc.titleInfections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group
dc.typeJournal Article
dc.rights.holderCellot et al.; licensee BioMed Central Ltd.
CollectionLibre accès - Publications // Open Access - Publications