Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group

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dc.contributor.authorCellot, Sonia
dc.contributor.authorJohnston, Donna
dc.contributor.authorDix, David
dc.contributor.authorEthier, Marie-Chantal
dc.contributor.authorGillmeister, Biljana
dc.contributor.authorMitchell, David
dc.contributor.authorYanofsky, Rochelle
dc.contributor.authorLewis, Victor
dc.contributor.authorPortwine, Carol
dc.contributor.authorPrice, Victoria
dc.contributor.authorZelcer, Shayna
dc.contributor.authorSilva, Mariana
dc.contributor.authorBowes, Lynette
dc.contributor.authorMichon, Bruno
dc.contributor.authorStobart, Kent
dc.contributor.authorBrossard, Josee
dc.contributor.authorBeyene, Joseph
dc.contributor.authorSung, Lillian
dc.date.accessioned2015-12-18T10:53:28Z
dc.date.available2015-12-18T10:53:28Z
dc.date.issued2013-06-04
dc.identifier.citationBMC Cancer. 2013 Jun 04;13(1):276
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2407-13-276
dc.identifier.urihttp://hdl.handle.net/10393/33571
dc.description.abstractAbstract Background It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly diagnosed APL and to describe factors associated with these infections. Methods We conducted a retrospective, population-based cohort study that included children ≤ 18 years of age with de novo APL treated at 15 Canadian centers. Thirty-three children with APL were included; 78.8% were treated with APL -specific protocols. Results Bacterial sterile site infection occurred in 12 (36.4%) and fungal sterile site infection occurred in 2 (6.1%) children. Of the 127 chemotherapy courses, 101 (79.5%) were classified as intensive and among these, the proportion in which a sterile site microbiologically documented infection occurred was 14/101 (13.9%). There was one infection-related death. Conclusions One third of children with APL experienced at least one sterile site bacterial infection throughout treatment and 14% of intensive chemotherapy courses were associated with a microbiologically documented sterile site infection. Infection rates in pediatric APL may be lower compared to non- APL acute myeloid leukemia although these children may still benefit from aggressive supportive care during intensive chemotherapy.
dc.titleInfections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group
dc.typeJournal Article
dc.date.updated2015-12-18T10:53:28Z
dc.language.rfc3066en
dc.rights.holderCellot et al.; licensee BioMed Central Ltd.
CollectionLibre accès - Publications // Open Access - Publications

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