Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group

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Title: Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group
Authors: Cellot, Sonia
Johnston, Donna
Dix, David
Ethier, Marie-Chantal
Gillmeister, Biljana
Mitchell, David
Yanofsky, Rochelle
Lewis, Victor
Portwine, Carol
Price, Victoria
Zelcer, Shayna
Silva, Mariana
Bowes, Lynette
Michon, Bruno
Stobart, Kent
Brossard, Josee
Beyene, Joseph
Sung, Lillian
Date: 2013-06-04
Abstract: Abstract Background It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly diagnosed APL and to describe factors associated with these infections. Methods We conducted a retrospective, population-based cohort study that included children ≤ 18 years of age with de novo APL treated at 15 Canadian centers. Thirty-three children with APL were included; 78.8% were treated with APL -specific protocols. Results Bacterial sterile site infection occurred in 12 (36.4%) and fungal sterile site infection occurred in 2 (6.1%) children. Of the 127 chemotherapy courses, 101 (79.5%) were classified as intensive and among these, the proportion in which a sterile site microbiologically documented infection occurred was 14/101 (13.9%). There was one infection-related death. Conclusions One third of children with APL experienced at least one sterile site bacterial infection throughout treatment and 14% of intensive chemotherapy courses were associated with a microbiologically documented sterile site infection. Infection rates in pediatric APL may be lower compared to non- APL acute myeloid leukemia although these children may still benefit from aggressive supportive care during intensive chemotherapy.
URL: http://dx.doi.org/10.1186/1471-2407-13-276
http://hdl.handle.net/10393/33571
CollectionLibre accès - Publications // Open Access - Publications
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