Associations between a neurophysiological marker of central cholinergic activity and cognitive functions in young and older adults

FieldValue
dc.contributor.authorYoung-Bernier, Marielle
dc.contributor.authorKamil, Yael
dc.contributor.authorTremblay, François
dc.contributor.authorDavidson, Patrick S R
dc.date.accessioned2015-11-05T21:52:25Z
dc.date.available2015-11-05T21:52:25Z
dc.date.created2012
dc.date.issued2012-04-26
dc.identifier.citationBehavioral and Brain Functions. 2012 Apr 26;8(1):17
dc.identifier.urihttp://dx.doi.org/10.1186/1744-9081-8-17
dc.identifier.urihttp://hdl.handle.net/10393/33145
dc.description.abstractAbstract Background The deterioration of the central cholinergic system in aging is hypothesized to underlie declines in several cognitive domains, including memory and executive functions. However, there is surprisingly little direct evidence regarding acetylcholine’s specific role(s) in normal human cognitive aging. Methods We used short-latency afferent inhibition (SAI) with transcranial magnetic stimulation (TMS) as a putative marker of cholinergic activity in vivo in young (n = 24) and older adults (n = 31). Results We found a significant age difference in SAI, concordant with other evidence of cholinergic decline in normal aging. We also found clear age differences on several of the memory and one of the executive function measures. Individual differences in SAI levels predicted memory but not executive functions. Conclusion Individual differences in SAI levels were better predictors of memory than executive functions. We discuss cases in which the relations between SAI and cognition might be even stronger, and refer to other age-related biological changes that may interact with cholinergic activity in cognitive aging.
dc.titleAssociations between a neurophysiological marker of central cholinergic activity and cognitive functions in young and older adults
dc.typeJournal Article
dc.date.updated2015-11-04T07:03:05Z
dc.language.rfc3066en
dc.rights.holderYoung-Bernier et al.; licensee BioMed Central Ltd.
CollectionLibre accès - Publications // Open Access - Publications

Files