The effects of ketogenic diets and ketosis on cognition in Alzheimer's disease

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Title: The effects of ketogenic diets and ketosis on cognition in Alzheimer's disease
Authors: Halili, Rina
Date: 2015-04-11
Abstract: BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disorder that destroys brain cells and causes deterioration of cognitive ability and memory. Alzheimer’s affects roughly seven percent of Canadians over 65 years of age. There is no cure for the disease and current care is primarily focused on symptom management. A dietary approach to treat AD may potentially provide an effective and low-cost intervention until the causative mechanism of disease is determined. The ketogenic diet is a high- fat, low carbohydrate diet that has been established as an effective, non-pharmacological treatment for epilepsy. Its use in inducing ketosis has also been implicated in a variety of neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Ketosis results in the production of ketone bodies, an alternate fuel source to glucose for the brain when carbohydrates are unavailable. OBJECTIVE: A review of the literature was conducted to assess the effectiveness of a ketogenic diet and ketosis induction in improving memory function in those with AD. METHODS: A structured literature review was executed. Three databases were consulted: PubMed (Medline), Google Scholar, and the Cochrane Library (Wiley). The keywords used were “ketogenic diet” (or specific components including “ketosis” and “ketone bodies”), “Alzheimer’s disease”, and “memory function” (or synonyms). RESULTS: Twenty-three relevant articles were chosen for review. However, only five studies met the inclusion criteria for analysis. CONCLUSIONS: To date, only a limited number of studies on the effects of ketogenic diets specifically on Alzheimer’s in humans have been conducted. The five studies that examined humans with AD did show improvement of memory performance after establishing ketosis, although not necessarily through traditional dietary means. However, animal models of Alzheimer’s have shown an improvement in cognitive performance with ketogenic diets and ketosis induction. These results warrant more clinical trials in humans and overall further elucidation amongst individuals with Alzheimer’s.
URL: http://hdl.handle.net/10393/32322
CollectionSciences de la santé - Affiches // Health Sciences - Research Posters
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