Improving Medication Adherence Post-ST-Elevation Myocardial Infarction

FieldValue
dc.contributor.authorSchwalm, Jon-David
dc.date.accessioned2015-02-27T17:56:43Z
dc.date.available2016-02-27T09:00:09Z
dc.date.created2015
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10393/32110
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-5721
dc.description.abstractST-segment elevation myocardial infarction (STEMI) is a common presentation of acute myocardial infarction, constituting approximately 30% of all cases. Based on the highest level of evidence for improvement in both morbidity and mortality in these patients, clinical guidelines from around the world support the prolonged use of secondary preventative medications (e.g., acetylsalicylic acid, second antiplatelet [clopidogrel, prasugrel, and ticagrelor], statin, beta-blocker, and angiotensin blocker). While in-hospital and discharge prescription rates for these essential life-saving medications is excellent, adherence is known to decline within weeks of hospital discharge. This decline in evidence-based medication use was confirmed in a population of patients with coronary artery disease in Ontario (Chapter 3). Furthermore, it was demonstrated that this decline was consistent across all medication classes and subgroups of patients. We developed a protocol (Chapter 4) for a cluster-randomized controlled trial evaluating the impact of repeated reminders sent by mail to the family physician and the patient, starting one month after the STEMI. The fifth chapter highlights the results of the cluster-randomized controlled trial, which demonstrates suboptimal persistence to all 4 of 4 cardiac medication classes at 12-months. There was no significant difference compared to usual care in the use of guideline-recommended medications post-STEMI when participants (and their family physicians) receive repeated postal reminders.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectAdherence
dc.subjectMyocardial Infarction
dc.subjectMedication
dc.titleImproving Medication Adherence Post-ST-Elevation Myocardial Infarction
dc.typeThesis
dc.contributor.supervisorGrimshaw, Jeremy
dc.embargo.terms2016-02-27 00:00:00
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineMédecine / Medicine
uottawa.departmentÉpidémiologie et médecine sociale / Epidemiology and Community Medicine
CollectionThèses, 2011 - // Theses, 2011 -

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