The Biology and Interplay of Immunotherapy by Leukemia-Oncolytic Virus (iLOV) Immune Responses

FieldValue
dc.contributor.authorTsang, Jovian
dc.date.accessioned2014-12-10T18:57:09Z
dc.date.available2014-12-10T18:57:09Z
dc.date.created2015
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10393/31873
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-6770
dc.description.abstractOncolytic viruses (OVs) are novel biological agents that selectively infect and kill malignant cells. OVs can also generate anti-cancer immunity. Our lab exploited this phenomenon and developed an in vitro vaccine with infected leukemia cells with oncolytic virus vaccine – and named immunotherapy by leukemia-oncolytic virus (iLOV) – that provided in vivo protection in a murine model for acute lymphoblastic leukemia. This work further characterizes iLOV biology and the interaction of its immune responses. An in vitro immune response assay was optimized to detect and quantify the in vivo anti-leukemia immunity generated by iLOV. Anti-viral immunity is an obstacle for OV therapy. Although iLOV created anti-viral antibodies towards itself, these neutralizing antibodies did not hinder the vaccine’s ability to initiate complement or dendritic cell activation. We envision personalized versions of iLOV for leukemia patients in remission to prevent the possibility of relapse. This work highlights new advantages for infected cell vaccines and supports the progress of iLOV toward clinical testing.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectOncolytic virus
dc.subjectCancer immunotherapy
dc.subjectHumoral immunity
dc.subjectImmunology
dc.subjectCancer therapy
dc.subjectAcute lymphoblastic leukemia
dc.titleThe Biology and Interplay of Immunotherapy by Leukemia-Oncolytic Virus (iLOV) Immune Responses
dc.typeThesis
dc.faculty.departmentBiochimie, microbiologie et immunologie / Biochemistry, Microbiology and Immunology
dc.contributor.supervisorBell, John
dc.contributor.supervisorAtkins, Harold
dc.degree.nameMSc
dc.degree.levelmasters
dc.degree.disciplineMédecine / Medicine
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineMédecine / Medicine
uottawa.departmentBiochimie, microbiologie et immunologie / Biochemistry, Microbiology and Immunology
CollectionThèses, 2011 - // Theses, 2011 -

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