Human Serum PCSK9 Is Elevated at Parturition in Comparison to Nonpregnant Subjects While Serum PCSK9 from Umbilical Cord Blood is Lower Compared to Maternal Blood

FieldValue
dc.contributor.authorPeticca, Patricia
dc.contributor.authorRaymond, Angela
dc.contributor.authorGruslin, Andrée
dc.contributor.authorCousins, Marion
dc.contributor.authorAdetola, Ejibunmi
dc.contributor.authorAbujrad, Hussein
dc.contributor.authorMayne, Janice
dc.contributor.authorOoi, Teik Chye
dc.date.accessioned2014-10-01T01:00:08Z
dc.date.available2014-10-01T01:00:08Z
dc.date.created2013
dc.date.issued2013
dc.identifier.citationISRN Endocrinology Volume 2013 (2013), Article ID 341632
dc.identifier.issn2090-4630
dc.identifier.urihttp://hdl.handle.net/10393/31654
dc.identifier.urihttp://www.hindawi.com/journals/isrn/2013/341632/
dc.description.abstractBackground. Serum lipids including total cholesterol (TC), triglycerides (TG), and low density lipoprotein cholesterol (LDL-C) are increased in pregnancy. Serum proprotein convertase subtilisin kexin 9 (PCSK9) is a significant player in lipoprotein metabolism. Circulating PCSK9 downregulates the LDL receptor on the surface of the liver, inhibiting clearance of LDL-C. Therefore, our study assessed serum PCSK9 concentrations at parturition (Maternal) compared to a nonpregnant (Control) cohort, as well as between mother and newborn (Maternal and Newborn). Methods. Blood was collected from women at parturition and from umbilical cords. Serum lipids and PCSK9 were measured and data were analysed for significance by Mann-Whitney U test at P < 0.05 and presented as median levels. Spearman's correlations were made at a 95% confidence interval. Results. Serum PCSK9 was significantly higher in Maternal versus Control cohorts (493.1 versus 289.7 ng/mL; P < 0.001, resp.), while the Newborn cohort was significantly lower than Maternal (278.2 versus 493.1 ng/mL; P < 0.0001, resp.). PCSK9 was significantly correlated with TC and HDL-C in Maternal and with TC, LDL-C, and HDL-C in Newborn cohorts. Conclusions. Our study provides the first quantitative report on PCSK9 in pregnancy (at parturition) and in umbilical cord blood. Further research will determine how these changes may affect lipoprotein levels during this physiological state.
dc.language.isoen
dc.titleHuman Serum PCSK9 Is Elevated at Parturition in Comparison to Nonpregnant Subjects While Serum PCSK9 from Umbilical Cord Blood is Lower Compared to Maternal Blood
dc.typeArticle
dc.identifier.doi10.1155/2013/341632
CollectionPublications en libre accès financées par uOttawa // uOttawa financed open access publications

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