Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli

Description
Title: Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli
Authors: Stevens, David Cole
Conway, Kyle R
Pearce, Nelson
Villegas-Peñaranda, Luis Roberto
Garza, Anthony G
Boddy, Christopher N
Date: 2013-05-28
Abstract: Heterologous expression of bacterial biosynthetic gene clusters is currently an indispensable tool for characterizing biosynthetic pathways. Development of an effective, general heterologous expression system that can be applied to bioprospecting from metagenomic DNA will enable the discovery of a wealth of new natural products.
URL: http://hdl.handle.net/10393/31499
DOI: doi:10.1371/journal.pone.0064858
CollectionLibre accès uOttawa - Publications // uOttawa Open Access - Publications
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