| Field | Value |
|---|
| dc.contributor.author | Alazzabi, Mufida |
| dc.date.accessioned | 2013-11-07T17:24:59Z |
| dc.date.available | 2013-11-07T17:24:59Z |
| dc.date.created | 2004 |
| dc.date.issued | 2004 |
| dc.identifier.citation | Source: Masters Abstracts International, Volume: 43-06, page: 2097. |
| dc.identifier.uri | http://hdl.handle.net/10393/26561 |
| dc.identifier.uri | http://dx.doi.org/10.20381/ruor-18246 |
| dc.description.abstract | The purpose of this research was to determine whether expression analysis of the IGF2 gene in zebrafish, a gene whose transcription is known to be regulated by DNA methylation in mammals, can be used as a marker or indicator of DNA methylation due to toxin exposure in fish embryos. We examined the expression of IGF2, IGF1, and IGFBP-1 in zebrafish embryos treated with sodium arsenite (thought to inhibit DNA methylation), nickel chloride (thought to cause DNA hypermethylation), trichostatin A (a histone deacetylase inhibitor), 5-azaC (thought to cause methyltransferase inhibition), cadmium chloride (thought to cause DNA hypermethylation) and mercury chloride (unknown). (Abstract shortened by UMI.) |
| dc.format.extent | 153 p. |
| dc.language.iso | en |
| dc.publisher | University of Ottawa (Canada) |
| dc.subject.classification | Biology, Molecular. |
| dc.title | Insulin-like growth factor-II (IGF2) gene of zebrafish and its use as a biogenetic marker for the assay of epigenetic toxin exposure |
| dc.type | Thesis |
| dc.degree.name | M.Sc. |
| dc.degree.level | Masters |
| Collection | Thèses, 1910 - 2010 // Theses, 1910 - 2010
|