Insulin-like growth factor-II (IGF2) gene of zebrafish and its use as a biogenetic marker for the assay of epigenetic toxin exposure

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dc.contributor.authorAlazzabi, Mufida
dc.date.accessioned2013-11-07T17:24:59Z
dc.date.available2013-11-07T17:24:59Z
dc.date.created2004
dc.date.issued2004
dc.identifier.citationSource: Masters Abstracts International, Volume: 43-06, page: 2097.
dc.identifier.urihttp://hdl.handle.net/10393/26561
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-18246
dc.description.abstractThe purpose of this research was to determine whether expression analysis of the IGF2 gene in zebrafish, a gene whose transcription is known to be regulated by DNA methylation in mammals, can be used as a marker or indicator of DNA methylation due to toxin exposure in fish embryos. We examined the expression of IGF2, IGF1, and IGFBP-1 in zebrafish embryos treated with sodium arsenite (thought to inhibit DNA methylation), nickel chloride (thought to cause DNA hypermethylation), trichostatin A (a histone deacetylase inhibitor), 5-azaC (thought to cause methyltransferase inhibition), cadmium chloride (thought to cause DNA hypermethylation) and mercury chloride (unknown). (Abstract shortened by UMI.)
dc.format.extent153 p.
dc.language.isoen
dc.publisherUniversity of Ottawa (Canada)
dc.subject.classificationBiology, Molecular.
dc.titleInsulin-like growth factor-II (IGF2) gene of zebrafish and its use as a biogenetic marker for the assay of epigenetic toxin exposure
dc.typeThesis
dc.degree.nameM.Sc.
dc.degree.levelMasters
CollectionTh├Ęses, 1910 - 2010 // Theses, 1910 - 2010

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