Informed Decision Making for Patients with Advanced Pancreatic Cancer Considering Chemotherapy: Development and Evaluation of a Clinical Decision Aid for Patients

FieldValue
dc.contributor.authorGresham, Gillian
dc.date.accessioned2013-08-13T14:34:15Z
dc.date.available2014-08-14T08:00:07Z
dc.date.created2013
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/10393/24395
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-6694
dc.description.abstractPancreatic cancer is the fourth leading cause of cancer death in Canada. Significant advancements in chemotherapy for advanced pancreatic cancer have resulted in the need for a quantitative comparison between these treatments on a relative scale. Therefore, a systematic review and Bayesian network meta-analysis of randomized clinical trials was conducted using gemcitabine, the standard treatment, as the reference comparator. Based on results from the network meta-analysis, in which optimal treatments were identified and side effects of each treatment evaluated, an Internet-based patient decision aid was developed in order to present the benefits and risks of each therapy option: (1) Best supportive care (2) gemcitabine (3) FOLFIRINOX. The objective of the decision aid was to guide patients through the decision-making process based on their individual preferences and values. The decision aid was deemed to be acceptable and feasible based on results from a pilot study conducted at The Ottawa Hospital Cancer Centre.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectAdvanced Pancreatic Cancer
dc.subjectChemotherapy
dc.subjectSystematic Review
dc.subjectNetwork meta-analysis
dc.subjectDecision Aid
dc.subjectGemcitabine
dc.subjectFOLFIRINOX
dc.subjectAcceptability
dc.subjectFeasibility
dc.titleInformed Decision Making for Patients with Advanced Pancreatic Cancer Considering Chemotherapy: Development and Evaluation of a Clinical Decision Aid for Patients
dc.typeThesis
dc.faculty.departmentÉpidémiologie et médecine sociale / Epidemiology and Community Medicine
dc.contributor.supervisorWells, George
dc.embargo.terms1 year
dc.degree.nameMSc
dc.degree.levelmasters
dc.degree.disciplineMédecine / Medicine
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineMédecine / Medicine
uottawa.departmentÉpidémiologie et médecine sociale / Epidemiology and Community Medicine
CollectionThèses, 2011 - // Theses, 2011 -

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