Podocytopenia in Diabetic Nephropathy: A Role for the Thromboxane A2 TP Receptor

FieldValue
dc.contributor.authorBugnot, Gwendoline Carine Denise
dc.date.accessioned2013-04-15T20:56:53Z
dc.date.available2013-04-15T20:56:53Z
dc.date.created2013
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/10393/24021
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-2930
dc.description.abstractAlthough the etiology of diabetic nephropathy is still uncertain, proteinuria due to podocyte injury and loss (podocytopenia) are early features of the disease. Significant increases in thromboxane A2 (TXA2) production as well as expression of its receptor in animal models of diabetic nephropathy led to the hypothesis that TXA2 acting via its thromboxane-prostanoid (TP) receptor induces podocytopenia resulting in proteinuria. Systemic infusion of a TP antagonist demonstrated an important role of TXA2/TP signalling in our model of streptozotocin induced type-1 diabetic nephropathy by reducing kidney damage including proteinuria. Podocyte specific TP overexpressing mice did not demonstrate more pathologic or dynamic kidney damage than non-transgenic mice in STZ-induced diabetic nephropathy. Further assessment of the TP transgene functionality in this mice line is necessary to validate those results. Whereas the importance of TXA2/TP signalling is undeniable in diabetic nephropathy, it appears that podocyte TP receptors might not be directly targeted.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectPodocyte
dc.subjectDiabetic nephropathy
dc.subjectTP receptor
dc.subjectThromboxane A2
dc.subjectProteinuria
dc.subjectSQ29548
dc.subjectArachidonic acid
dc.titlePodocytopenia in Diabetic Nephropathy: A Role for the Thromboxane A2 TP Receptor
dc.typeThesis
dc.faculty.departmentMédecine cellulaire et moléculaire / Cellular and Molecular Medicine
dc.contributor.supervisorKennedy, Christopher
dc.embargo.termsimmediate
dc.degree.nameMSc
dc.degree.levelmasters
dc.degree.disciplineMédecine / Medicine
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineMédecine / Medicine
uottawa.departmentMédecine cellulaire et moléculaire / Cellular and Molecular Medicine
CollectionThèses, 2011 - // Theses, 2011 -

Files