Snf2l Regulates Foxg1 Expression to Control Cortical Progenitor Cell Proliferation and Differentiation

FieldValue
dc.contributor.authorMcGregor, Chelsea P.
dc.date.accessioned2012-09-05T20:38:53Z
dc.date.available2012-09-05T20:38:53Z
dc.date.created2012
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10393/23231
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-5975
dc.description.abstractOver the past five years the role of epigenetic modifiers in brain development has become increasingly evident. In this regard, Snf2l, a homolog of the chromatin remodeling protein ISWI, was shown to have enriched expression in the brain and be important for neuronal differentiation. Mice lacking functional Snf2l have hypercellularity of the cerebral cortex due to increased cell cycle re-entry. In this thesis I demonstrate the effects of Snf2l-ablation on cortical progenitor cells including increased proliferation and cell cycle deregulation, the consequence of which is a delay in neuronal migration and altered numbers of mature cortical neurons. This phenotype arises from increased expression of Foxg1, a winged-helix repressor expressed in the forebrain and anterior optic vesicle. Moreover, genetically reducing its overexpression rescues the Snf2l-ablated phenotype. Snf2l is bound directly to a promoter region of Foxg1 suggesting that it acts as a repressive regulator in vivo and is an important factor in forebrain differentiation.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectSnf2l
dc.subjectFoxg1
dc.subjectChromatin Remodeling
dc.subjectCerebral Cortex
dc.subjectDevelopment
dc.subjectForebrain
dc.subjectEpigenetic
dc.titleSnf2l Regulates Foxg1 Expression to Control Cortical Progenitor Cell Proliferation and Differentiation
dc.typeThesis
dc.faculty.departmentBiochimie, microbiologie et immunologie / Biochemistry, Microbiology and Immunology
dc.contributor.supervisorPicketts, David
dc.embargo.termsimmediate
dc.degree.nameMSc
dc.degree.levelmasters
dc.degree.disciplineMédecine / Medicine
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineMédecine / Medicine
uottawa.departmentBiochimie, microbiologie et immunologie / Biochemistry, Microbiology and Immunology
CollectionThèses, 2011 - // Theses, 2011 -

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